Results 11 to 20 of about 1,675,474 (298)

DosEmi study protocol: a phase IV, multicentre, open-label, crossover study to evaluate non-inferiority of pharmacokinetic-guided reduced dosing compared with conventional dosing of emicizumab in people with haemophilia A

BMJ Open, 2023
Introduction Emicizumab effectively prevents bleeding in people with haemophilia A (PwHA), but is a burden for national healthcare budgets and consequently may limit access.
Marjon H Cnossen, Karin Fijnvandraat, Ron Mathot, Antoine C G Egberts, Rolf T Urbanus, Anouk Donners, Konrad van der Zwet, Ilmar Kruis, Roger Schutgens, Kathelijn Fischer   +9 more
doaj   +1 more source

Possible Targets to Reduce Fatigue in Chronic Immune Thrombocytopenia Patients – An Explorative Study

TH Open, 2022
Background Fatigue in immune thrombocytopenia (ITP) is frequent and burdensome, but we lack the knowledge to help these patients. Aim The aim of the study is to explore the role of disease activity and other potentially modifiable factors in ...
Wobke E.M. van Dijk, Merel M. Nap-van der Vlist, Hans Knoop, Roger E.G. Schutgens   +3 more
doaj   +1 more source

Benign lymphangioendothelioma

Journal of the American Academy of Dermatology, 1994
We describe a 40-year-old white man with a red-brown, indurated plaque on the proximal aspect of his right thigh. The lesion had been present since birth, and the patient had a 20-year clinical history of recurrent cellulitis in the same area. The histopathologic features of the lesion included permeation of the dermis by flattened, endothelium-lined ...
G S, Herron, R V, Rouse, J C, Kosek, B R, Smoller, B M, Egbert   +4 more
openaire   +2 more sources

Laparoscopic Hysterectomy versus Abdominal Hysterectomy for Obese Women with Benign Diseases [PDF]

International Journal of Medical Arts, 2020
Background: Obesity is a challenging health problem in gynecologic surgery. Laparoscopic has the potential advantages than abdominal hysterectomy of being quicker, efficient with low estimated blood loss.Aim of the work: To compare the safety and ...
Mohamed Thapet, Mahmoud Farouk Midan, Mahmoud Rady, Hossam Abdou   +3 more
doaj   +1 more source

High bleeding rates in δ-storage pool disease during surgeries and deliveries

Research and Practice in Thrombosis and Haemostasis
Background: δ-storage pool disease (δ-SPD) involves various platelet disorders due to deficient or reduced secretion of dense granules, causing increased bleeding tendency, particularly during surgery and delivery.
Elleke van Heerwaarde, Annick de Moor, Albert Huisman, Rolf Urbanus, Idske Kremer Hovinga, Roger Schutgens   +5 more
doaj   +1 more source

Models for integrating toxicology concepts into chemistry courses and programs

Green Chemistry Letters and Reviews, 2017
Toxicology and related concepts are being taught within chemistry education programs to enable students to (1) develop an awareness of toxicological principles and concepts that are otherwise absent from the chemistry curriculum for undergraduates and (2)
Amy S. Cannon, David Finster, Douglas Raynie, John C. Warner   +3 more
doaj   +1 more source

No correlation between thrombin generation and emicizumab levels: implications for monitoring emicizumab therapy

Research and Practice in Thrombosis and Haemostasis
Background: Emicizumab, a bispecific antibody that mimics factor (F)VIII, has significantly improved hemophilia A management. Although emicizumab levels can be measured, tools for estimating the hemostatic efficacy of emicizumab are lacking.
Konrad van der Zwet, Mark Roest, Dana Huskens, Roger E.G. Schutgens, Lize F.D. van Vulpen, Kathelijn Fischer, Rolf T. Urbanus   +6 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Retroperitoneal Lipoblastoma-A Rare Entity [PDF]

Journal of Clinical and Diagnostic Research, 2018
Lipoblastomas are uncommon tumours which can achieve enormous size and volumes occurring in young paediatric population predominantly. Retroperitoneal locations of these tumours are very rare and only a few cases have been noted in the literature.
Suhitha Gajanthody, Harshavardhan Gowda, Ashraf Ahamed, Anuradha CK Rao, MR Shashidhar   +4 more
doaj   +1 more source

Benign lymphoepithelial cyst of parotid gland: A pathologist's perspective

Journal of Cytology, 2023
Benign lymphoepithelial cyst (BLEC) of the salivary gland is a gradually increasing cystic lesion commonly associated with human immunodeficiency virus (HIV) infection. In rare instances, it can be seen in immunocompetent patients.
Sampa Choudhury
doaj   +1 more source