Results 11 to 20 of about 1,594,605 (248)

Predicting Individual Changes in Terminal Half-Life After Switching to Extended Half-Life Concentrates in Patients With Severe Hemophilia

HemaSphere, 2022
Predicting individual effects of switching from standard half-life (SHL) to extended half-life (EHL) FVIII/FIX concentrates is pivotal in clinical care, but large-scale individual data are scarce. The aim of this study was to assess individual changes in
Olav Versloot, Emma Iserman, Pierre Chelle, Federico Germini, Andrea N. Edginton, Roger E. G. Schutgens, Alfonso Iorio, Kathelijn Fischer, on behalf of the prophylaxis working group of the International Prophylaxis Study Group*   +8 more
doaj   +1 more source

Possible Targets to Reduce Fatigue in Chronic Immune Thrombocytopenia Patients – An Explorative Study

TH Open, 2022
Background Fatigue in immune thrombocytopenia (ITP) is frequent and burdensome, but we lack the knowledge to help these patients. Aim The aim of the study is to explore the role of disease activity and other potentially modifiable factors in ...
Wobke E.M. van Dijk, Merel M. Nap-van der Vlist, Hans Knoop, Roger E.G. Schutgens   +3 more
doaj   +1 more source

Benign lymphangioendothelioma

Journal of the American Academy of Dermatology, 1994
We describe a 40-year-old white man with a red-brown, indurated plaque on the proximal aspect of his right thigh. The lesion had been present since birth, and the patient had a 20-year clinical history of recurrent cellulitis in the same area. The histopathologic features of the lesion included permeation of the dermis by flattened, endothelium-lined ...
G S, Herron, R V, Rouse, J C, Kosek, B R, Smoller, B M, Egbert   +4 more
openaire   +2 more sources

High bleeding rates in δ-storage pool disease during surgeries and deliveries

Research and Practice in Thrombosis and Haemostasis
Background: δ-storage pool disease (δ-SPD) involves various platelet disorders due to deficient or reduced secretion of dense granules, causing increased bleeding tendency, particularly during surgery and delivery.
Elleke van Heerwaarde, Annick de Moor, Albert Huisman, Rolf Urbanus, Idske Kremer Hovinga, Roger Schutgens   +5 more
doaj   +1 more source

Laparoscopic Hysterectomy versus Abdominal Hysterectomy for Obese Women with Benign Diseases [PDF]

International Journal of Medical Arts, 2020
Background: Obesity is a challenging health problem in gynecologic surgery. Laparoscopic has the potential advantages than abdominal hysterectomy of being quicker, efficient with low estimated blood loss.Aim of the work: To compare the safety and ...
Mohamed Thapet, Mahmoud Farouk Midan, Mahmoud Rady, Hossam Abdou   +3 more
doaj   +1 more source

Models for integrating toxicology concepts into chemistry courses and programs

Green Chemistry Letters and Reviews, 2017
Toxicology and related concepts are being taught within chemistry education programs to enable students to (1) develop an awareness of toxicological principles and concepts that are otherwise absent from the chemistry curriculum for undergraduates and (2)
Amy S. Cannon, David Finster, Douglas Raynie, John C. Warner   +3 more
doaj   +1 more source

Platelets induce VISTA expression and modulate the ovarian tumor microenvironment

Platelets
Immune checkpoint regulators, such as the V-domain Ig suppressor of T cell activation (VISTA), play a critical role in shaping the tumor microenvironment (TME) and facilitating immune evasion.
Hani Lee, Brianne Sager, Anil Sood, Vahid Afshar-Kharghan, Min Soon Cho   +4 more
doaj   +1 more source

No correlation between thrombin generation and emicizumab levels: implications for monitoring emicizumab therapy

Research and Practice in Thrombosis and Haemostasis
Background: Emicizumab, a bispecific antibody that mimics factor (F)VIII, has significantly improved hemophilia A management. Although emicizumab levels can be measured, tools for estimating the hemostatic efficacy of emicizumab are lacking.
Konrad van der Zwet, Mark Roest, Dana Huskens, Roger E.G. Schutgens, Lize F.D. van Vulpen, Kathelijn Fischer, Rolf T. Urbanus   +6 more
doaj   +1 more source

Stressful Events Reported by Childhood Cancer Survivors and Community Controls From the St. Jude Lifetime (SJLIFE) Cohort: A Mixed Method Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Characterizing stressful events reported by childhood cancer survivors experienced throughout the lifespan may help improve trauma‐informed care relevant to the survivor experience. Methods Participants included 2552 survivors (54% female; 34 years of age) and 469 community controls (62% female; 33 years of age) from the St.
Megan E. Ware, Colter K. Clayton, Fang Wang, Sedigheh Mirzaei, Kyla Shelton, Tara M. Brinkman, Victoria Willard, Katianne M. Howard Sharp, Kevin Krull, Lindsay F. Schwartz, Melissa M. Hudson, Gregory T. Armstrong, Kirsten K. Ness, Rachel T. Webster   +13 more
wiley   +1 more source

Utility of Computed Tomography Surveillance of Asymptomatic Infection in Children and Young Adults Before Allogeneic Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Asymptomatic infection poses a significant risk for children undergoing hematopoietic stem cell transplantation (HSCT). Pre‐transplant surveillance computed tomography (CT) is commonly used to identify occult infection, though its diagnostic yield remains uncertain.
Tyler Obermark, Pradipta Debnath, Rama S. Ayyala, Lara A. Danziger‐Isakov, Jane Koo, Kasiani C. Myers, William R. Otto, Aki Tanimoto, Andrew T. Trout, Cara E. Morin   +9 more
wiley   +1 more source