Results 21 to 30 of about 1,675,474 (298)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
A Review of Posteromedial Lesions of the Chest Wall: What Should a Chest Radiologist Know?
Diagnostics, 2022 A heterogeneous group of tumors can affect the posteromedial chest wall. They form diverse groups of benign and malignant (primary or secondary) pathologies that can arise from different chest wall structures, i.e., fat, muscular, vascular, osseous, or ...
Sara Haseli +7 more
doaj +1 more source
The Journal of Bone and Joint Surgery. British volume, 1966 1. Benign chondroblastoma is a rare primary neoplasm of bone with excellent prognosis. It is believed that instances of it are still being missed. 2. Six cases are described with special emphasis on diagnostic pitfalls. 3. A critical survey of the literature and a discussion on nomenclature and histogenesis are included.
openaire +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist
Research and Practice in Thrombosis and HaemostasisBackground: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders.
Minka Zivkovic +74 more
doaj +1 more source
Curve-Based Classification Approach for Hyperspectral Dermatologic Data Processing
Sensors, 2021 This paper shows new contributions in the detection of skin cancer, where we present the use of a customized hyperspectral system that captures images in the spectral range from 450 to 950 nm.
Stig Uteng +8 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions
Biomedicines, 2021 Meningiomas are the most common intracranial tumor, making up more than a third of all primary central nervous system (CNS) tumors. They are mostly benign tumors that can be observed or preferentially treated with gross total resection that provides good
Christian Ogasawara +2 more
doaj +1 more source
Ear, Nose & Throat Journal, 1980 A case is presented, and the histogenesis and treatment of this unusual tumor are discussed.
J B, Carter, D, Brady
openaire +2 more sources