Results 111 to 120 of about 30,899 (241)

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

Unveiling the Anticancer Properties of New Synthesized Alkoxy‐ and Methyl Thio‐Chalcone Derivatives

Natural Sciences, Volume 6, Issue 2, April 2026.
ABSTRACT Breast and cervical cancers are a serious problem and the leading cause of death in women in this decade. Chalcone is a promising compound with great potential for anticancer use. In this work, we synthesized six chalcone derivatives with alkoxy‐ and methylthio‐substituents through Claisen–Schmidt condensation at room temperature.
Nurcahyo Iman Prakoso, Taiki Umezawa, Dwiarso Rubiyanto, Azizah Zelia Kusumo, Fanny Septianingtyas, Muhamad Ikhsan Nurochman, Laras Kristianti, Salmahaminati, Pinus Jumaryatno, Minori Abe   +9 more
wiley   +1 more source

Solar Flow Synthesis of Polymer Nanoparticles: Scaling Local Experiments to Global Potential

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
The large‐scale sunlight‐induced photochemical synthesis of polymer nanoparticles based on the Diels–Alder step‐growth polymerization of a bismaleimide and a difunctional o‐methylbenzaldehyde in a self‐built solar flow reactor is introduced. Furthermore, a framework is established to translate sunlight‐driven experimental results globally—validated in ...
Jochen A. Kammerer, Joshua O. Holloway, Theresa Stephan, Hartmut Gliemann, Florian Feist, Fred Pashley‐Johnson, Laura Delafresnaye, Christopher Barner‐Kowollik   +7 more
wiley   +2 more sources

On‐Demand Chemically Degradable Hydrogels for Biological Applications

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
This review explores the mechanisms and kinetics of chemically induced on‐demand degradation in hydrogels designed for painless dressing removal and traceless dissolution across various biological applications. Covalent bond cleavage and noncovalent disruption triggers are compared, highlighting opportunities for load‐bearing scaffolds with faster ...
Xinyi Sheng, Justin Kim
wiley   +1 more source

Stereoselective Bio‐Organocatalytic Cascade to Chiral Amides as Active Pharmaceutical Ingredient Intermediates Using ω‐Transaminase and Choline Chloride Under Microwave Irradiation

ChemSusChem, Volume 19, Issue 6, 27 March 2026.
Amide bond formation is central to active pharmaceutical ingredient (API) synthesis. A bio‐organocatalytic cascade is reported, merging stereoselective ω‐transaminase (ω‐TA) transamination in neat organic solvent with choline chloride‐mediated amidation under solvent‐free microwave conditions.
Salvatore Romano, Matteo Damian, Monica Nardi, Antonio Procopio, Sebastian Strähler, Daniël Preschel, Manuela Oliverio, Francesco G. Mutti   +7 more
wiley   +1 more source

Unraveling Defect-Dependent Conductivity-Type Switching in CuFe₂O₄ for Enhanced Photoelectrocatalytic Reduction of Benzaldehyde. [PDF]

ACS Appl Mater Interfaces
Huang YC, Mohanta MK, Fong JL, Reyes AM, Reyes-Lillo SE, Jiang CM.   +5 more
europepmc   +1 more source

From freshness to preservation: insights into processing and storage impacts on purple passion fruit volatilome

Journal of the Science of Food and Agriculture, Volume 106, Issue 4, Page 2139-2153, 15 March 2026.
Abstract BACKGROUND Purple passion fruit is highly appreciated for its distinctive sweet flavour, low acidity, and aromatic profile, making it a desirable choice for fresh consumption and juice production. To ensure microbiological safety and extend shelf life, juice products typically undergo thermal pasteurization, which can alter their ...
Alexandre MA Fonseca, Carlos A Pinto, Jorge A Saraiva, Armando JD Silvestre, Sílvia M Rocha   +4 more
wiley   +1 more source

Synthesis, Characterization, Molecular Docking, and Preliminary Biological Evaluation of 2-((4-Morpholino-1,2,5-thiadiazol-3-yl)oxy)benzaldehyde. [PDF]

Molecules
Motente M, Chude-Okonkwo UAK.
europepmc   +1 more source

Synthesis, Biological Evaluation, and Theoretical Study of Indenoquinolinylphosphine Oxide Derivatives as Topoisomerase 1 Inhibitors and Antiproliferative Agents

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
The topoisomerase I inhibition and antiproliferative activities of phosphorated indenoquinoline derivatives were investigated. The target hybrid quinoline and tetrahydroquinoline compounds were synthesized via a two‐step Povarov‐type cycloaddition.
Alba Rodriguez, Elena Formoso, Birgitta R. Knudsen, Cinzia Tesauro, Maria Fuertes, Concepcion Alonso   +5 more
wiley   +1 more source

Machine learning-based QSAR modeling assay for the nitrification inhibition of 2,4,5-trichloroaniline-derived eco-friendly Schiff bases. [PDF]

RSC Adv
Mondal T, Kumar R, Mukherjee S, Mridha N, Laskar N, Das A, Basak P, Singha A, Sinha K, Shakyawar DB.   +9 more
europepmc   +1 more source