Results 21 to 30 of about 4,330 (166)

Jarisch‐Herxheimer reaction among HIV‐positive patients with early syphilis: azithromycin versus benzathine penicillin G therapy

Journal of the International AIDS Society, 2014
Introduction The Jarisch‐Herxheimer reaction, a febrile inflammatory reaction that often occurs after the first dose of chemotherapy in spirochetal diseases, may result in deleterious effects to patients with neurosyphilis and to pregnant women. A single
Mao‐Song Tsai, Chia‐Jui Yang, Nan‐Yao Lee, Szu‐Min Hsieh, Yu‐Hui Lin, Hsin‐Yun Sun, Wang‐Huei Sheng, Kuan‐Yeh Lee, Shan‐Ping Yang, Wen‐Chun Liu, Pei‐Ying Wu, Wen‐Chien Ko, Chien‐Ching Hung   +12 more
doaj   +1 more source

Tolerability of IM penicillin G benzathine diluted or not with local anesthetics, or different gauge needles for syphilis treatment: a randomized clinical trial

BMC Infectious Diseases, 2019
Background Penicillin G Benzathine (PGB) is the cornerstone of syphilis treatment. However, its intramuscular (IM) administration is associated with pain at the site of injection.
Vicente Estrada, Eva Santiago, Inmaculada Cabezas, Juan Luis Cotano, Juan Carlos Carrió, Manuel Fuentes-Ferrer, Mar Vera, Oskar Ayerdi, Carmen Rodríguez, Laura López, Noemí Cabello, María José Núñez, Teresa Puerta, Iñigo Sagastagoitia, Jorge Del Romero   +14 more
doaj   +1 more source

Clinical trial protocol to evaluate the efficacy of cefixime in the treatment of early syphilis

Trials, 2020
Background Syphilis rates have been increasing both in the USA and internationally with incidence higher among men-who-have-sex-with-men and people living with human immunodeficiency virus (HIV) infection.
Shivani N. Mehta, Chrysovalantis Stafylis, David M. Tellalian, Pamela L. Burian, Cliff M. Okada, Carl E. Millner, Christopher M. Mejia, Jeffrey D. Klausner   +7 more
doaj   +1 more source

A Rare Case of Neurosyphilis with Calvaria Osteitis Presenting in Pregnancy

Case Reports in Obstetrics and Gynecology, 2023
Background. The incidence of syphilis throughout the world is increasing. Rates in pregnancy are similarly rising, presenting risks of an untreated syphilis infection that can be detrimental to the mother and fetus.
Gisella M. Newbery, Christine E. Henricks, Julie A. Vircks, Andreina Colina, David C. Mundy   +4 more
doaj   +1 more source

Early syphilis: serological treatment response to doxycycline/tetracycline versus benzathine penicillin

Journal of Infection in Developing Countries, 2014
Introduction: Benzathine penicillin G is the treatment of choice for syphilis, but doxycycline and tetracycline are effective second-line treatments. The objective of this study was to assess the serological response to treatment for early syphilis with ...
Jun Li, He-Yi Zheng
doaj   +1 more source

Secondary Syphilis With Concomitant Bullous Pemphigoid: A Case Report. [PDF]

Case Rep Dermatol Med
A 52‐year‐old woman presented with a three‐month history of pruritic scaly palmoplantar eruptions that progressed to tense bullae over trunk and extremities along with genital mucosal involvement. Serology confirmed syphilis (VDRL reactive at 1:16 and TPHA positive), and biopsy with direct immunofluorescence (DIF) established bullous pemphigoid (BP ...
Rijal S, Sitaula D, Gyawalee M, Paudel V, Kafle M, Khadka A, Magar ST, Paudel B, Jha A, Amatya A, Kayastha B.   +10 more
europepmc   +2 more sources

Prolonged benzathine penicillin G improves long-term serological outcomes in HIV-negative neurosyphilis: a multicenter study exploring prognostic factors and therapeutic outcomes

International Journal of Infectious Diseases
Objectives: Neurosyphilis is a serious complication of Treponema pallidum infection. Some patients experience relapse or serofast response despite standard intravenous penicillin G. While adjunctive benzathine penicillin is recommended in some guidelines,
Beilin Luo, Ting Wang, Shiyong Li, Nengsheng Wu, Nan Sheng, Shunpo He, Qingwei Yang   +6 more
doaj   +1 more source

Kounis syndrome associated with benzathine penicillin G use: A case report

Dermatologica Sinica, 2013
Kounis syndrome is a life-threatening medical condition that causes severe allergic reaction and acute coronary syndrome. Benzathine penicillin G is one of the most widely used antibiotics in clinical practice, but it can enhance both allergic and ...
Arif Duran, Tarık Ocak, Serkan Öztürk, Nadir Goksugur   +3 more
doaj   +1 more source

Longitudinal Variations in the tprK Gene of Treponema pallidum in an Amoy Strain-Infected Rabbit Model

Microbiology Spectrum, 2023
Heterogeneous tprK sequences have been hypothesized to be an important factor for persistent infection of Treponema pallidum subsp. pallidum (T. pallidum) in humans.
Dan Liu, Rui Chen, Yun He, Yong-jing Wang, Li-Rong Lin, Li-Li Liu, Tian-Ci Yang, Man-Li Tong   +7 more
doaj   +1 more source

Serum penicillin G levels are lower than expected in adults within two weeks of administration of 1.2 million units. [PDF]

PLoS ONE, 2011
When introduced in the 1950s, benzathine penicillin G (BPG) was shown to be effective in eradicating group A beta-hemolytic streptococcus (GAS) for at least 3 weeks after administration.
Michael P Broderick, Christian J Hansen, Kevin L Russell, Edward L Kaplan, Jeffrey L Blumer, Dennis J Faix   +5 more
doaj   +1 more source