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Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters

Bioorganic & Medicinal Chemistry, 2004
In our effort to delineate novel pharmacophoric configuration of bioisosteric pyran versions of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine derivatives in interacting with the monoamine transporter, further structure-activity relationship study was carried out.
Shijun, Zhang   +3 more
openaire   +2 more sources

Possible effect of hyperconjugation on solvolysis rates of benzhydryl chlorides and spectra of related compounds

Tetrahedron, 1959
Abstract The near ultraviolet absorption spectra of a series of benz cyclo alkenes have been determined. A minimum in the absorption band near 270 mμ has been observed for benz cyclo heptene. It appears significant that this same inflexion occurs in the solvolysis rates for the related benzhydryl chlorides.
W.R. Moore   +3 more
openaire   +1 more source

Organometallic Compounds of the Lanthanides. 179.1 Synthesis and Structural Characterization of a Mixed Alkyl (Benzhydryl, Trimethylsilylmethyl) Lutetium Complex

Organometallics, 2006
The reaction of LuCl3(THF)3 with 2 equiv of LiCH2SiMe3 and 1 equiv of KCHPh2 (1) affords Lu(CH2SiMe3)2(CHPh2)(THF)2 (2). X-ray structural analyses show the benzhydryl unit to be planar in 1, but bent in 2.
Herbert Schumann   +2 more
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Activation of the C–C Bond Using Brønsted Acid NaHSO4/SiO2: Synthesis of Triarylmethanes from 3-Benzhydryl Pentane-2,4-dione and Aromatic Compounds

Synlett, 2014
A novel and efficient method for the activation of the C(sp 3 )–C(sp 3 ) bond was developed. The C(sp 3 )–C(sp 3 ) bond in 3-benzhydryl pentane-2,4-dione was easily cleaved in the presence of NaHSO 4 /SiO 2 to form benzhydryl cation which reacted with aromatic compounds at 110 °C for five to six hours to afford triarylmethanes in good yields.
Tadashi Aoyama   +7 more
openaire   +1 more source

COMPARATIVE SPASMOLYTIC ACTIVITIES OF CERTAIN BENZHYDRYL ALKAMINE ETHERS AND RELATED COMPOUNDS

The Journal of Pharmacology and Experimental Therapeutics, 1949
G A, ALLES, M A, REDEMANN
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Synthetic antispasmodics II. Benzhydryl β-diethylaminopropionate and related compounds

Collection of Czechoslovak Chemical Communications, 1950
Z. J. Vejdělek, M. Protiva
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