Results 11 to 20 of about 167 (133)

Effect of Pesticides on Peroxisome Proliferator‐Activated Receptors (PPARs) and Their Association with Obesity and Diabetes

open access: yesPPAR Research, Volume 2023, Issue 1, 2023., 2023
Obesity and diabetes mellitus are considered the most important diseases of the XXI century. Recently, many epidemiological studies have linked exposure to pesticides to the development of obesity and type 2 diabetes mellitus. The role of pesticides and their possible influence on the development of these diseases was investigated by examining the ...
J. Hernández-Valdez   +3 more
wiley   +1 more source

Benzil bis(ketazine) [PDF]

open access: yesActa Crystallographica Section E Structure Reports Online, 2009
1,1',2,2' -tetra-fenil-2,2 '-azinodietanona), C(28)H(20)N(2)O(2), se obtuvo mediante la reacción de bencil monohidrazona con nitrato de cromo(III). La unidad de dibencil-ideno hidrazina es casi plana (desviación r.m.s. = 0.073 Å) y las dos unidades de benzoílo están orientadas casi perpendiculares a ella [ángulo diedro = 87.81 (2), 87.81 (2) °].
Goutam K. Patra   +2 more
openaire   +3 more sources

Heterolytic O−O Bond Cleavage Upon Single Electron Transfer to a Nonheme Fe(III)−OOH Complex

open access: yesChemistry – A European Journal, Volume 28, Issue 53, September 22, 2022., 2022
The one‐electron reduction of a nonheme FeIII(OOH) intermediate results in the release of the FeII(OH) complex and O2, following a bimolecular reaction consistent with the disproportionation of the hydroperoxo ligand in a putative FeII(OOH) species. One plausible mechanistic scenario is that this disproportionation reaction follows an O−O heterolytic ...
Antoine Bohn   +6 more
wiley   +1 more source

Pharmacological and molecular characterization of the A‐type muscarinic acetylcholine receptor from Anopheles gambiae

open access: yesInsect Molecular Biology, Volume 31, Issue 4, Page 497-507, August 2022., 2022
A‐type mAChR was identified in Anopheles gambiae larvae and adult mosquitoes Activation of An. gambiae mAChR‐A which is coupled to phosphoinositide pathway induced intracellular calcium increase An. gambiae mAChR‐A is mainly blocked by 4‐DAMP known as M3 mAChR antagonist in mammals Summary showing the pharmacology of Anopheles gambiae mAChR‐A and its ...
Alexandre Pilon   +2 more
wiley   +1 more source

Spatial Covariance of Cholinergic Muscarinic M1/M4 Receptors in Parkinson's Disease

open access: yesMovement Disorders, Volume 36, Issue 8, Page 1879-1888, August 2021., 2021
ABSTRACT Background Parkinson's disease (PD) is associated with cholinergic dysfunction, although the role of M1 and M4 receptors remains unclear. Objective To investigate spatial covariance patterns of cholinergic muscarinic M1/M4 receptors in PD and their relationship with cognition and motor symptoms.
Sean J. Colloby   +7 more
wiley   +1 more source

Microwave-assisted Heterogeneous Benzil–Benzilic Acid Rearrangement [PDF]

open access: yesJournal of Chemical Research, 1999
A new procedure for carrying out the benzil–benzilic acid rearrangement in the solid state has been developed which provides a new route to synthesize the pharmacologically interesting anticonvulsant dilantin.
Hui-Ming Yu   +4 more
openaire   +2 more sources

Assessment of zebrafish embryo photomotor response sensitivity and phase‐specific patterns following acute‐ and long‐duration exposure to neurotoxic chemicals and chemical weapon precursors

open access: yesJournal of Applied Toxicology, Volume 40, Issue 9, Page 1272-1283, September 2020., 2020
Abstract Zebrafish are an attractive model for chemical screening due to their adaptability to high‐throughput platforms and ability to display complex phenotypes in response to chemical exposure. The photomotor response (PMR) is an established and reproducible phenotype of the zebrafish embryo, observed 24 h post‐fertilization in response to a ...
Chance M. Carbaugh   +6 more
wiley   +1 more source

NEMS Resonators for Detection of Chemical Warfare Agents Based on Graphene Sheet

open access: yesMathematical Problems in Engineering, Volume 2019, Issue 1, 2019., 2019
Graphene sheets are the basis of nanoelectromechanical (NEMS) mass resonators that are in recent years experimentally used for detection of specific gas molecules in air. The aim of this paper is to theoretically investigate the possibility of application of graphene sheets in detection of Chemical Warfare Agents (CWA’s). By application of the nonlocal
Nikola Anđelić   +3 more
wiley   +1 more source

Preparation of Zirconium Oxide Powder Using Zirconium Carboxylate Precursors

open access: yesAdvances in Physical Chemistry, Volume 2014, Issue 1, 2014., 2014
Zirconia was prepared at low temperatures (<450°C) using single several source precursors based on zirconium carboxylates where the R groups were systematically varied. The combination of density functional theory (DFT) calculations and extensive characterization of the precursors (i.e., X‐ray diffraction, thermal gravimetric analysis, infrared ...
Mohammed H. Al-Hazmi   +3 more
wiley   +1 more source

Serum Anticholinergic Activity: A Possible Peripheral Marker of the Anticholinergic Burden in the Central Nervous System in Alzheimer’s Disease

open access: yesDisease Markers, Volume 2014, Issue 1, 2014., 2014
We review the utility of serum anticholinergic activity (SAA) as a peripheral marker of anticholinergic activity (AA) in the central nervous system (CAA). We hypothesize that the compensatory mechanisms of the cholinergic system do not contribute to SAA if their system is intact and that if central cholinergic system deteriorates alone in conditions ...
Koji Hori   +14 more
wiley   +1 more source

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