Results 41 to 50 of about 81 (79)

Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

Chemico-Biological Interactions, 1977
Abstract (±)-7β,8α-Dihydroxy-9β,10β-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (diol epoxide-1) and (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (diol epoxide-2) are highly mutagenic diol epoxide diastereomers that are formed during metabolism of the carcinogen (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene.
D R, Thakker, H, Yagi, H, Akagi, M, Koreeda, A H, Lu, W, Levin, A W, Wood, A H, Conney, D M, Jerina   +8 more
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Excretion of benzo[a]pyrene-Gua adduct in the urine of benzo[a]pyrene-treated rats

Chemico-Biological Interactions, 1986
A benzo[a]pyrene(BP)-Gua adduct was extracted in the urine of rats treated with BP. Some (0.15%) of the administered dose of BP was excreted as BP-Gua within 48 h. A double labelling experiment demonstrated that the excreted product contained both a BP and a Gua moiety.
Autrup, Herman, Seremet, T.
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Benzo[a]pyrene antibody inhibition of benzo[a]pyrene-induced mutagenesis

Cancer Letters, 1979
Summary An antibody to benzo[ a ]pyrene (BP) was prepared. The isolated antibody showed a specificity for BP and a low reactivity with another carcinogenic hydrocarbon, 7,12-dimethylbenz[ a ] anthracene (DMBA). The BP-antibody inhibited the in vitro cytotoxic and mutagenic activity of BP in both a rat embryo fibroblast- and a rat lung cell-mediated ...
Anna Tompa, Gary Curtis, Wayne Ryan, Charles Kuszynski, Robert Langenbach   +4 more
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Benzo[a]pyrene-collagen interactions

Chemico-Biological Interactions, 1983
In vitro interactions of benzo[a]pyrene (BaP) with acid-soluble type I collagen from rat tail tendon have been investigated. The fluorescence of BaP increases in the presence of collagen. Bound BaP inhibits the formation of collagen fibrils in solution.
E, Fujimori, D V, Crabtree
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Risk assessment for benzo[a]pyrene

Regulatory Toxicology and Pharmacology, 1991
Benzo[a]pyrene is the most studied carcinogenic polycyclic aromatic hydrocarbon and one of the most potent, and it is often used as a toxicological prototype or surrogate for all carcinogenic polycyclic aromatic hydrocarbons. Quantitative risk assessment of benzo[a]pyrene has been hampered by the quality of the data sets available for quantitation. The
J F, Collins, J P, Brown, S V, Dawson, M A, Marty   +3 more
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Metabolism of Benzo(a)Pyrene and Benzo(a)Pyrene 4,5-Oxide in Rabbit Lung

1982
For several years our laboratory has been investigating the biotransformation of various environmental pollutants by lung. Studies have been performed with pulmonary subcellular fractions, purified monooxygenase and glutathione transferase enzymes, and preparations having intact cellular structure including the isolated perfused lung and cell fractions
J R, Bend, B R, Smith, L M, Ball, J L, Plummer, C R, Wolf, R M, Philpot, T R, Devereux, J R, Fouts   +7 more
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PHARMACOKINETICS OF BENZO[a]PYRENE IN THE RAT

Journal of Toxicology and Environmental Health, Part A, 1998
Groups of 4 male Wistar rats were dosed intravenously with 14C-labeled benzo[a]pyrene dissolved in an Emulphor/water vehicle at 3 different dose levels and killed at 1 of 15 specific time intervals from 5 min to 32 h after dosing. 14C-Radiolabel concentration-time data were obtained for blood, brain, adipose, heart, kidney, liver, lung, spleen, and ...
D, Moir, A, Viau, I, Chu, J, Withey, E, McMullen   +4 more
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Wheat Bran and the Induction of Intestinal Benzo(a)pyrene Hydroxylase by Dietary Benzo(a)pyrene

The Journal of Nutrition, 1989
The mucosa of the intestine responds to polycyclic aromatic hydrocarbons (PAH) with the rapid induction of benzo(a)pyrene hydroxylase (BPH). Studies were conducted to determine if dietary fiber would reduce exposure of the intestine to dietary benzo(a)pyrene (BP) as indicated by intestinal BPH activity.
S K, Clinton, W J, Visek
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Analysis of tetrahydroxylated benzo[a]pyrene isomers in hair as biomarkers of exposure to benzo[a]pyrene

Analytical and Bioanalytical Chemistry, 2016
A first gas chromatography-tandem mass spectrometry (GC-MS/MS) method was designed for analysis of four tetrahydroxylated benzo[a]pyrene metabolites (benzo[a]pyrene-r-7,t-8,t-9,c-10-tetrahydrotetrol, benzo[a]pyrene-r-7,t-8,t-9,t-10-tetrahydrotetrol, benzo[a]pyrene-r-7,t-8,c-9,c-10-tetrahydrotetrol, and benzo[a]pyrene-r-7,t-8,c-9,t-10-tetrahydrotetrol ...
Nathalie, Grova, Emilie M, Hardy, Pauline, Meyer, Brice M R, Appenzeller   +3 more
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Microspectrofluorometric study of Benzo(a)pyrene metabolization in Benzo(a)pyrene-grown single living cells

Histochemistry, 1974
A microspectrofluorometric approach in conjunction with microelectrophoretic injection of glucose-6-P (G6P), was used to study the effect of cultivation in a benzo(a)pyrene (BP)-containing medium on the metabolization of BP, by EL2 ascites cells. The fluorescence increase which follows the microinjection of G6P to single living cells.
J M, Salmon, E, Kohen, C, Kohen, G, Bengtsson   +3 more
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