Results 51 to 60 of about 81 (79)
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Nature, 1983
It is fifty years since the publication of the report on the isolation, from coal tar, and identification of the potent chemical carcinogen benzo(a)pyrene, the culmination of over 10 years of research instigated and directed by E.L. Kennaway. The events leading to that discovery are of interest in themselves.
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It is fifty years since the publication of the report on the isolation, from coal tar, and identification of the potent chemical carcinogen benzo(a)pyrene, the culmination of over 10 years of research instigated and directed by E.L. Kennaway. The events leading to that discovery are of interest in themselves.
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Benzo(a)pyrene diolepoxide-haemoglobin and albumin adducts at low levels of benzo(a)pyrene exposure
Biomarkers, 2000A biomonitoring study was conducted to simultaneously measure individual benzo(a)pyrene (BaP) exposure in 50 office employees, not occupationally exposed to polycyclic aromatic hydrocarbons (PAH), using personal samplers and the formation of (+) r-7, t-8-dihyroxy-t-9,t-10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) adducts to haemoglobin (BPDE-Hb ...
R. Pastorelli +7 more
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2014
Cigarette smoking is the leading cause of preventable death in the United States. While there are more than 4,000 chemicals found in tobacco smoke, the polycyclic aromatic hydrocarbons (PAHs) have been clearly demonstrated to contribute to smoking-related cancers.
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Cigarette smoking is the leading cause of preventable death in the United States. While there are more than 4,000 chemicals found in tobacco smoke, the polycyclic aromatic hydrocarbons (PAHs) have been clearly demonstrated to contribute to smoking-related cancers.
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Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice
Nature, 1977THE pioneering research by James and Elizabeth Miller relating the carcinogenic effects of many chemicals to the metabolism of these compounds to reactive intermediates which bind to critical cellular compoenents1,2 led to studies of the nature and chemical structure of these reactive metabolites (ultimate carcinogens) and their metabolic precursors ...
J, Kapitulnik +4 more
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Analytical Biochemistry, 1976
Abstract A simple radioassay method is described to measure specifically and quantitatively the metabolic activation of the carcinogen benzo(a)pyrene (BP) to a derivative which reacts covalently with a macromolecular target molecule (protein). The NADPH2-dependent formation of this macromolecule-hydrocarbon complex during incubation with rat liver ...
F B, Thomas, N B, Furlong
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Abstract A simple radioassay method is described to measure specifically and quantitatively the metabolic activation of the carcinogen benzo(a)pyrene (BP) to a derivative which reacts covalently with a macromolecular target molecule (protein). The NADPH2-dependent formation of this macromolecule-hydrocarbon complex during incubation with rat liver ...
F B, Thomas, N B, Furlong
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Biochemical Pharmacology, 1986
Previously reported inhibitors of benzo[a]pyrene (BaP) mutagenicity in Salmonella typhimurium strain TA98 were tested for their effectiveness against the mutagenicity of 6-methyl-benzo[a]pyrene (6-CH3-BaP), 6-hydroxymethyl-benzo[a]pyrene (6-CH2OH-BaP) and 6-acetoxymethyl-benzo[a]pyrene (6-CH3COOCH2-BaP). Dose-response curves obtained for phenothiazine (
J H, Bayless +3 more
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Previously reported inhibitors of benzo[a]pyrene (BaP) mutagenicity in Salmonella typhimurium strain TA98 were tested for their effectiveness against the mutagenicity of 6-methyl-benzo[a]pyrene (6-CH3-BaP), 6-hydroxymethyl-benzo[a]pyrene (6-CH2OH-BaP) and 6-acetoxymethyl-benzo[a]pyrene (6-CH3COOCH2-BaP). Dose-response curves obtained for phenothiazine (
J H, Bayless +3 more
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Carcinogenesis, 1982
Human serum lipoproteins were isolated by means of size exclusion h.p.l.c. Non-covalent uptake of [3H]benzo[a]pyrene was quantitated for fractions collected from the effluent of a liquid chromatographic separation of human serum, and was found to directly correlate with the lipoprotein concentration.
D L, Busbee +3 more
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Human serum lipoproteins were isolated by means of size exclusion h.p.l.c. Non-covalent uptake of [3H]benzo[a]pyrene was quantitated for fractions collected from the effluent of a liquid chromatographic separation of human serum, and was found to directly correlate with the lipoprotein concentration.
D L, Busbee +3 more
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Dietary effects on the uptake of benzo[a]pyrene
Food and Chemical Toxicology, 1994It has been established that exposure to polycyclic aromatic hydrocarbons (PAHs), or more specifically benzo[a]pyrene (B[a]P), either by inhalation through cigarette smoking or by contact through occupational exposure of the lungs or skin, can result in cancerous lesions.
B, Stavric, R, Klassen
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Radioimmunoassay for benzo[a]pyrene.
Journal of the National Cancer Institute, 1978A benzo[a]pyrene (BP)-bovine serum albumin conjugate was synthesized and used to immunize 2.5- to 3.0-kg New Zealand White rabbits. The resulting antisera to BP bound trace amounts of [3H] (55 pg; 6,000 counts/min). A radioimmunoassay (RIA) to BP was developed by the antiserum first being titered with the [3H]BP and then a standard curve being ...
N Y, Kado, E T, Wei
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Mutagenicity and Carcinogenicity of Benzo[a]pyrene and Benzo[a]pyrene Derivatives
1978W. LEVIN +8 more
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