Results 251 to 260 of about 132,663 (305)
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International Anesthesiology Clinics, 1988
The structure of the GABAA receptor, through which GABA--the main inhibitory neurotransmitter in the mammalian CNS--produces its major synaptic effects, has recently been identified. The GABAA receptor is a member of a family of receptor-operated ion channels to which the nicotinic cholinergic receptor-cation channel and the glycine receptor-anion ...
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The structure of the GABAA receptor, through which GABA--the main inhibitory neurotransmitter in the mammalian CNS--produces its major synaptic effects, has recently been identified. The GABAA receptor is a member of a family of receptor-operated ion channels to which the nicotinic cholinergic receptor-cation channel and the glycine receptor-anion ...
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Anaesthesia, 1983
It appeared recently that the important group of psychoactive drugs, the benzodiazepines, binds with high affinity to a single class of saturable sites on brain membranes of all higher vertebrates including man. There was a good correlation between the pharmacological effects of different benzodiazepines and their affinity for 3H-diazepam and 3H ...
C, Braestrup, M, Nielsen
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It appeared recently that the important group of psychoactive drugs, the benzodiazepines, binds with high affinity to a single class of saturable sites on brain membranes of all higher vertebrates including man. There was a good correlation between the pharmacological effects of different benzodiazepines and their affinity for 3H-diazepam and 3H ...
C, Braestrup, M, Nielsen
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984
Dependence to benzodiazepines is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but provide no proper epidemiological framework for the estimation of risk.
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Dependence to benzodiazepines is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but provide no proper epidemiological framework for the estimation of risk.
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The American Journal of Drug and Alcohol Abuse, 1991
Two cases of intranasal benzodiazepine use are presented. The methods of preparation and administration of the powder and accounts of the pharmacological effects of the drugs used are described. The pattern of development and progress of the habit and its associated features are delineated.
M F, Sheehan +4 more
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Two cases of intranasal benzodiazepine use are presented. The methods of preparation and administration of the powder and accounts of the pharmacological effects of the drugs used are described. The pattern of development and progress of the habit and its associated features are delineated.
M F, Sheehan +4 more
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British Journal of Addiction, 1991
AbstractBenzodiazepines present problems related to both unwanted and withdrawal effects. Dosage adjustments usually obviate unwanted effects except for paradoxical reactions such as hostility. Patients with apparent benzodiazepine dependence need careful assessment with respect to personality, social situation and psychiatric disorder.
M, Lader, S, Morton
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AbstractBenzodiazepines present problems related to both unwanted and withdrawal effects. Dosage adjustments usually obviate unwanted effects except for paradoxical reactions such as hostility. Patients with apparent benzodiazepine dependence need careful assessment with respect to personality, social situation and psychiatric disorder.
M, Lader, S, Morton
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2015
Benzodiazepines have been in clinical use since the 1960s. Benzodiazepines act through allosteric modulation of the GABAA receptor to enhance the activity of GABA, an inhibitory neurotransmitter, resulting in a slowing of neurotransmission and sedative and anxiolytic effects.
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Benzodiazepines have been in clinical use since the 1960s. Benzodiazepines act through allosteric modulation of the GABAA receptor to enhance the activity of GABA, an inhibitory neurotransmitter, resulting in a slowing of neurotransmission and sedative and anxiolytic effects.
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Prior Benzodiazepine Exposure and Benzodiazepine Treatment Outcome
The Journal of Clinical Psychiatry, 2000We examined discontinuation symptoms following brief benzodiazepine therapy (8 weeks) and intermittent benzodiazepine therapy (2 weeks with at least 2 weeks without drug) and associations with prior benzodiazepine use. The hypothesis was that prior benzodiazepine use would predispose patients to more severe discontinuation symptoms.Data were drawn from
K, Rickels, E W, Freeman
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Therapie, 2000
The existence of endogenous benzodiazepines such as diazepam and nordiazepam has been provided in human blood and brains as well as in medicinal plants and foods. It must be stressed, however, that in plasma and brain tissue there are also other benzodiazepine-like compounds termed 'endozepines' which are not halogenated.
BARALDI, Mario +5 more
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The existence of endogenous benzodiazepines such as diazepam and nordiazepam has been provided in human blood and brains as well as in medicinal plants and foods. It must be stressed, however, that in plasma and brain tissue there are also other benzodiazepine-like compounds termed 'endozepines' which are not halogenated.
BARALDI, Mario +5 more
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The Canadian Journal of Psychiatry, 1981
This report summarizes pertinent biochemical, pharmacological and clinical information on the effects of abrupt cessation of benzodiazepine therapy. The need to discriminate between distress (anxiety) due to recurrences, rebound phenomena and withdrawal syndromes is emphasized.
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This report summarizes pertinent biochemical, pharmacological and clinical information on the effects of abrupt cessation of benzodiazepine therapy. The need to discriminate between distress (anxiety) due to recurrences, rebound phenomena and withdrawal syndromes is emphasized.
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American Nurse Journal, 2023
Take a crash course in use, misuse, complications, and withdrawal.
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Take a crash course in use, misuse, complications, and withdrawal.
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