Results 91 to 100 of about 158,750 (352)
Epilepsia, EarlyView.Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden +5 more
wiley +1 more source
Zdravniški Vestnik, 2013 Benzodiazepines abuse in drug using population has become a large problem in many countries. The authors present the problem of use and misuse of benzodiazepines in drug using population in Slovenia and recommendations for prescribing benzodiazepines to ...
Andrej Kastelic, Nuša Šegrec
doaj
Beyond classical benzodiazepines: Novel therapeutic potential of GABAA receptor subtypes
Nature reviews. Drug discovery, 2011 GABAA (γ-aminobutyric acid, type A) receptors are a family of ligand-gated ion channels that are essential for the regulation of central nervous system function.
U. Rudolph, F. Knoflach
semanticscholar +1 more source
Benzodiazepines : benefits versus risks [PDF]
, 2007 Benzodiazepines act on the central nervous system and can be prescribed for various medical conditions. They are usually classified by their duration of action.
West, Lorna Marie
core
Iridium Catalyzed Asymmetric Hydrogenation of Cyclic Imines of Benzodiazepinones and Benzodiazepines
, 2012 Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee.
Wu, Bo +6 more
core +1 more source
Effect of epileptogenesis on hypercapnic cardioventilatory response in kainic acid rats
Epilepsia, EarlyView.Abstract Objective Cardioventilatory failure is the leading mechanism proposed to underlie sudden unexpected death in epilepsy (SUDEP), which occurs predominantly at night in patients with generalized tonic–clonic seizures. Interictal hypercapnic cardioventilatory responses are suggested to be involved, as they are ablated in chronically epileptic ...
Auriane Apaire +7 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive therapy for drug‐resistant idiopathic generalized epilepsy (IGE) with generalized tonic–clonic seizures (GTCSs). Methods NAUTILUS is a prospective, multicenter, single‐blind, randomized sham‐controlled pivotal trial ...
Utku Uysal +47 more
wiley +1 more source
Safety of benzodiazepines and opioids in very severe respiratory disease: national prospective study
British medical journal, 2014 Objective To evaluate the safety of benzodiazepines and opioids in patients with very severe chronic obstructive pulmonary disease (COPD). Design Population based longitudinal consecutive cohort study. Setting Centres prescribing long term oxygen therapy
M. Ekström +3 more
semanticscholar +1 more source
Perspectives on drugs: The misuse of benzodiazepines among high-risk opioid users in Europe.
, 2015 Benzodiazepines are a widely prescribed group of medicines with a range of clinical uses, including the treatment of anxiety and insomnia and the management of alcohol withdrawal.
core
Benzodiazepines: sedation and agitation
, 2016 Dental anxiety is common and frequently poses a barrier to necessary dental treatment. The increasing availability of conscious sedation in dental practice has made treatment much more accessible for anxious patients. At present, benzodiazepines are the
Catherine Gallagher
core +1 more source