Results 111 to 120 of about 131,739 (305)

Self‐limited neonatal epilepsy with 2q24.3 duplications: Case series and literature review

open access: yesEpileptic Disorders, EarlyView.
Abstract Objective To clarify the phenotypic spectrum associated with duplications involving the 2q24.3 region, which includes a cluster of genes encoding sodium channel subunits (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A). Methods We reviewed our research database for patients with epilepsy and 2q24.3 duplication and performed thorough phenotyping.
Saba Al Rawahi, Kenneth A. Myers
wiley   +1 more source

Sleep Hygiene In Danbury CT: Providing a Resource to Prompt and Initiate Behavior Change [PDF]

open access: yes, 2017
Sleeplessness is a problem encountered frequently in the primary care setting, and often is inappropriately addressed by prescribing pharmacological intervention for indefinite periods of time.
Franco, Sebastian A
core   +1 more source

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

open access: yesEpilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin   +7 more
wiley   +1 more source

Dispensing of zolpidem and benzodiazepines in Brazilian private pharmacies: a retrospective cohort study from 2014 to 2021

open access: yesFrontiers in Pharmacology
ObjectiveThe study aimed to evaluate Zolpidem and Benzodiazepines prescription and dispensing data in private pharmacies in Brazil from 2014 to 2021. Methods: This retrospective cohort study was carried out with retrospective open data from the Brazilian
Fabiana Carvalho   +4 more
doaj   +1 more source

Stiripentol: Unpublished results from the first phase 2 clinical trial in Lennox–Gastaut syndrome conducted in the early 1990s

open access: yesEpilepsia, EarlyView.
Abstract Objective This study was undertaken to present the results of an exploratory phase 2 trial of stiripentol in Lennox–Gastaut syndrome (LGS). Methods This exploratory single‐blind, single‐arm, nonrandomized sequential‐period phase 2 study was conducted at four centers in France between January 1989 and August 1993.
Stéphane Auvin   +3 more
wiley   +1 more source

Responding to Substance Use in Racialized Communities in Canada in the Current Polysubstance Era

open access: yesCanadian Journal of Bioethics
Racialized people experience excess and preventable harm from substance use, raising questions about how justice ought to be pursued via health policy.
Manisha Pahwa, Chetan Mehta
doaj   +1 more source

Did the French pregnancy pictogram change antiseizure medication use during pregnancy?

open access: yesEpilepsia, EarlyView.
Abstract Objective The aim of this study was to assess the impact of introducing a pregnancy pictogram on medication packaging on the prescription and dispensation of antiseizure medications and on the maternal and neonatal outcomes for women exposed to these medications.
Mélanie Araujo   +7 more
wiley   +1 more source

Detecting benzodiazepine use through induced eye convergence inability with a smartphone app: a proof-of-concept study

open access: yesFrontiers in Digital Health
BackgroundBenzodiazepines (BZDs) are readily available potent drugs that act as central depressants. These drugs are widely used, misused, and abused. For patients with BZD use disorder, the traditional sobriety monitoring method is periodic urine tests ...
Kiki W. K. Kuijpers   +12 more
doaj   +1 more source

Treating Insomnia in General Practice [PDF]

open access: yes, 2007
LS is a 13-year-old boy who presented with a one month history of difficulty in falling asleep. He was accompanied by his mother, who asked that he be prescribed some form of sleeping pill to solve the problem, because she was worried that it was ...
Camilleri, Mark
core  

Women with epilepsy: Evidence‐based counseling across the lifespan

open access: yesEpilepsia, EarlyView.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn   +7 more
wiley   +1 more source

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