Results 1 to 10 of about 98,705 (330)

Diazepam causes sedative rather than anxiolytic effects in C57BL/6J mice

Scientific Reports, 2021
Diazepam has been broadly accepted as an anxiolytic drug and is often used as a positive control in behavioral experiments with mice. However, as opposed to this general assumption, the effect of diazepam on mouse behavior can be considered rather ...
Marina Pádua-Reis, Diana Aline Nôga, Adriano B. L. Tort, Martina Blunder   +3 more
doaj   +2 more sources

Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers

Epilepsia, 2020
The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. Comparative agents were diazepam rectal gel, which served as the regulatory reference product; and oral diazepam, a product ...
Barry Gidal, Robert Hogan, Enrique Carrazana   +2 more
exaly   +2 more sources

Chronic Chrysin, but Not Diazepam, Induces Anxiolytic-like Effects Without Behavioral Tolerance [PDF]

Molecules
Background: Chrysin (5-7-dihydroxyflavone) exerts anxiolytic-like effects via the GABAA/benzodiazepine receptor complex after acute administration, similar to diazepam.
Luz María Nicio-Antonio, Gabriel Guillén-Ruiz, Ana Karen Limón-Vázquez, Jonathan Cueto-Escobedo, León Jesús Germán-Ponciano, Emma Virginia Herrera-Huerta, David Armando Argüello-Velasco, Juan Francisco Rodríguez-Landa   +7 more
doaj   +2 more sources

Classics in Chemical Neuroscience: Diazepam (Valium)

ACS Chemical Neuroscience, 2014
James Barrow
exaly   +2 more sources

Final results from a Phase 3, long‐term, open‐label, repeat‐dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy

Epilepsia, 2021
A Phase 3 open‐label safety study (NCT02721069) evaluated long‐term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters.
J. Wheless, I. Miller, R. Hogan, D. Dlugos, V. Biton, G. Cascino, Michael R. Sperling, K. Liow, B. Vazquez, Eric B. Segal, D. Tarquinio, Weldon Mauney, Jay Desai, A. Rabinowicz, E. Carrazana   +14 more
semanticscholar   +1 more source

Examining the patient and caregiver experience with diazepam nasal spray for seizure clusters: Results from an exit survey of a phase 3, open-label, repeat-dose safety study.

Epilepsy & Behavior, 2021
BACKGROUND Ideal rescue treatments for acute treatment of seizure clusters should be easy to administer, so it is important to assess user perceptions of these treatments.
P. Penovich, J. Wheless, R. Hogan, Cynthia Guerra, David F. Cook, E. Carrazana, A. Rabinowicz   +6 more
semanticscholar   +1 more source

Overcoming the challenges of developing an intranasal diazepam rescue therapy for the treatment of seizure clusters

Epilepsia, 2021
Seizure clusters must be treated quickly and effectively to prevent progression to prolonged seizures and status epilepticus. Rescue therapy for seizure clusters has focused on the use of benzodiazepines.
J. Cloyd, S. Haut, E. Carrazana, A. Rabinowicz   +3 more
semanticscholar   +1 more source

Influence of Internal Structure of the Sorbents on Diazepam Sorption from Simulated Intestinal Fluid

Applied Sciences, 2021
The capacity of natural Na-montmorillonite and activated charcoal for sorption of diazepam from simulated intestinal fluid (SIF) was studied. The main characteristics of the sorbents were determined.
Mircea Stefan, Ioana Stefan, Ioana-Alexandra Negoita, Viorel Ordeanu, Daniela Simina Stefan   +4 more
doaj   +1 more source

Diazepam in cardioversion [PDF]

Canadian Anaesthetists’ Society Journal, 1971
Ce travail decrit nos experiences au cours de 161 cardioversions par courant direct, dont 76 ont ete pratiquees sous anesthesie au diazepam seul et 85 sous anesthesie par divers agents. Generalement le premier choc etait de 100 watts seconde, et les suivants, si besoin, allaient en s’accroissant a partir de 100 watts seconde. Dans le groupe du diazepam,
L N, Vinge, G M, Wyant, J F, Lopez
openaire   +2 more sources

Effect of diazepam on some physiological and productive traits of Cobb hybrid broiler chickens [PDF]

Iraqi Journal of Veterinary Sciences, 2008
The study was carried out to investigate the effect of diazepam in drinking water on some productive and physiological traits of hybrid (Cobb500) broiler chickens.
H. M. Hameed, S. H. Tohala
doaj   +3 more sources