Results 41 to 50 of about 53,567 (294)

A prospective series of acute rivaroxaban overdose, coagulopathy and bleeding complications (ATOM 11)

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim There is limited research describing rivaroxaban overdose. We aim to describe rivaroxaban overdose, coagulopathy and bleeding complications. Methods This is a prospective series of acute adult (>14 years) rivaroxaban overdose presentations >40 mg enrolled in the Australian Toxicology Monitoring study and presenting to three Australian clinical ...
Katherine Z. Isoardi   +3 more
wiley   +1 more source

PENELITIAN KADAR OBAT GENERIK DIAZEPAM [PDF]

open access: yes, 1991
Penelitian obat didasarkan atas kualitasnya, oleh karena itu pabrik farmasi sepenuhnya bertanggung jawab terhadap kualitas obat yang diproduksinya. Terhadap tablet Diazepam telah dilakukan pemeriksaan baik secara kualitatif maupun secara kuantitatif. ~l
Soetomo Wardjowinoto, Drs. Apt   +1 more
core  

Intra-arterial injection of diazepam

open access: yes, 1996
Diazepam is frequently and safely used in a wide variety of medical settings. However, an accidental intra-arterial injection of diazepam can have serious sequelae. This report describes the case of a intra-arterial injection of diazepam and outlines the
Sean Rice, Ronald H Levine
core   +1 more source

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

open access: yesDrug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche   +5 more
wiley   +1 more source

Segmental Hair Analysis of Diphenhydramine and Cyclizine Following a Single Dose

open access: yesDrug Testing and Analysis, EarlyView.
A single oral dose of diphenhydramine and cyclizine can be quantified in human head hair for a minimum of 5 months and, in certain cases, for up to 1 year following intake. Among 12 study participants, the measured concentrations ranged from 0 to 610 pg/mg within 1 year post‐intake.
Jan Bílek   +3 more
wiley   +1 more source

Preconcentration and determination of diazepam in pharmaceutical and biological samples by graphene oxide based on dispersive solid phase microextraction [PDF]

open access: yesشیمی کاربردی روز, 2019
Graphene oxide (GO) has a great potential to use as an adsorbent in sample preparation procedures. In this research, GO was used as an effective adsorbent in a simple GO-based dispersive micro-solid phase extraction technique coupled with high ...
Nazpari Mirzaei   +2 more
doaj   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

open access: yesDrug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis   +5 more
wiley   +1 more source

Stiff person syndrome in a Nepalese man with uncontrolled diabetes mellitus and ketonuria: A rare case report

open access: yesClinical Case Reports, 2023
Stiff Person Syndrome (SPS), a progressive Central Nervous System disorder is accompanied by progressive muscle rigidity, hyperreflexia, and spasms mainly in truncal and proximal leg muscles mainly associated with autoimmune disorders.
Sanjeev Kharel   +9 more
doaj   +1 more source

Isolation and Characterization of Two New Secondary Metabolites From Quercus incana and Their Antidepressant- and Anxiolytic-Like Potential

open access: yesFrontiers in Pharmacology, 2018
The ethyl acetate fraction of Quercus incana yielded two new compounds [1 and 2]. The characterization and structure elucidation of these compounds were carried out through various spectroscopic techniques such as mass spectrometry along with one- and ...
Rizwana Sarwar   +10 more
doaj   +1 more source

Gallic Acid-Mediated Enhancement of Diazepam-Induced Sedation via GABA<sub>A</sub> Receptor Modulation: In Vivo and In Silico Evaluation. [PDF]

open access: yesFood Sci Nutr
Gallic acid (GA) dose‐dependently reduced sleep latency and prolonged sleep duration in thiopental sodium‐induced mice, with synergistic effects when combined with diazepam. Molecular docking revealed GA's higher binding affinity (−9.8 kcal/mol) to GABAA receptor (α1 and β2 subunits) than diazepam (−8.4 kcal/mol), suggesting GABAergic potential ...
Yana NT   +14 more
europepmc   +2 more sources

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