Results 61 to 70 of about 100,754 (275)

Late stage C―H activation of a privileged scaffold; synthesis of a library of benzodiazepines [PDF]

, 2016
A library of over twenty 5-(2-arylphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-ones has been formed by a microwave-mediated late-stage palladium-catalysed arylation of 1,4-benzodiazepines using diaryliodonium salts.
Abdelkafi, Algarra, Baghbanzadeh, Baud, Bedford, Bielawski, Bunin, Chuckowree, Ciana, Clark, Coles, Delvare, Diers, Duncton, Dupont, El Bouakher, Field, Filippakopoulos, Filippakopoulos, Gant, Gribble, He, Ho, Huang, Islam, Kaur, Kozhushkov, Kruegel, Lapointe, Liang, Liegault, Liu, Luo, Lyons, Ma, Ma, McDonald, McDonald, McNally, Merritt, Mirguet, Modha, Mwande-Maguene, Nadin, Nadres, Neufeldt, Noisier, O’Hara, Purser, Ren, Schulman, Sharma, Sharma, Spencer, Spencer, Spencer, Spencer, Sternbach, Trost, Wang, Wencel-Delord, Wu, Yamaguchi, Yang, Yotphan   +64 more
core   +1 more source

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Did the French pregnancy pictogram change antiseizure medication use during pregnancy?

Epilepsia, EarlyView.
Abstract Objective The aim of this study was to assess the impact of introducing a pregnancy pictogram on medication packaging on the prescription and dispensation of antiseizure medications and on the maternal and neonatal outcomes for women exposed to these medications.
Mélanie Araujo, Christine Damase‐Michel, Marie Denuelle, Sébastien Boulogne, Laurane Delteil, Monica Saucedo, Catherine Deneux‐Tharaux, Isabelle Lacroix   +7 more
wiley   +1 more source

Diazepam exposure associated with an increased risk of acute kidney injury in children: an observational cohort study

BMC Pediatrics
Background Potentially nephrotoxic drugs play an important role in acute kidney injury (AKI) in children. In the previous pharmacovigilance study, we found a statistical correlation between diazepam and AKI in children, but the causality needs to be ...
Miao Zhang, Liang Huang, Yu Zhu, Linan Zeng, Guo Cheng, Hailong Li, Lingli Zhang   +6 more
doaj   +1 more source

Pattern of utilization of benzodiazepines in patients with hypertension: A pilot study [PDF]

Vojnosanitetski Pregled, 2006
Background/Aim. The analysis of drug prescribing in general practice in Serbia showed that the use of benzodiazepines is most frequently associated with hypertension.
Divac Nevena, Veljković Slavomir, Nešić Zorica, Stojanović Radan, Bajčetić Milica, Vasiljević Zorana, Prostran Milica, Samardžić Ranka   +7 more
doaj   +1 more source

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

Use of Diazepam to Correct Hemodynamic Changes in Explosive Mine Injury: Experimental Study

Общая реаниматология, 2007
Objective. To study the hemodynamic effect of benzodiazepine tranquilizers in explosive mine injury in an experiment.Materials and methods. The study was performed on non-inbred male rats; hemodynamic parameters were examined at the systemic, organ, and ...
V. N. Yelsky, G. K. Krivobok, Ye. V. Antonov   +2 more
doaj   +1 more source

Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo

Frontiers in Pharmacology, 2020
BackgroundDiazepam is a benzodiazepine drug used to treat anxiety, insomnia, and muscle spasms. Imperatorin is a phytochemical isolated from medicinal plants and is widely used in herbal medicine. The aim of this study was to investigate the interactions
Yunfang Zhou, Deru Meng, Deru Meng, Feifei Chen, Zhengping Wu, Binglan Wang, Shuanghu Wang, Peiwu Geng, Dapeng Dai, Quan Zhou, Weiwen Qiu, Weiwen Qiu, Weiwen Qiu   +12 more
doaj   +1 more source

Current practices in managing acutely disturbed patients at three hospitals in Rio de Janeiro-Brazil: a prevalence study [PDF]

, 2002
The medical management of aggressive and violent behaviour is a critical situation for which there is little evidence. In order to prepare for a randomised trial, due to start in the psychiatric emergency rooms of Rio de Janeiro in 2001, a survey of ...
Adams, C.E., Carvalho, A, Coutinho, E, Fagundes, H.M., Gewandszajder, M, Huf, G, Keusen, A, Lopez, J, Oliveira, E.S.   +8 more
core  

Systematic statistical analysis of change in SEIzure interVAL with diazepam nasal spray supports this novel clinical endpoint for immediate‐use seizure medication

Epilepsia, EarlyView.
Abstract Objective Appropriate endpoints for daily antiseizure medications may differ from those for intermittent, immediate‐use seizure medications (ISMs). The observed interval between seizure clusters over time (SEIzure interVAL [SEIVAL]) has been proposed as a novel effectiveness endpoint for ISMs.
Wesley T. Kerr, Katherine N. McFarlane, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +4 more
wiley   +1 more source