Results 61 to 70 of about 53,567 (294)
Epilepsia, EarlyView.Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall +3 more
wiley +1 more source
Effects of chronic diazepam treatment and withdrawal on avoidance behavior
, 1999 The present study was designed to evaluate the effects of chronic diazepam (DZ) treatment with low doses and diazepam withdrawal on the two-way shuttle-box avoidance performance in rats. After 24 rats were randomly assigned into three groups (I mg/kg DZ,
Soygur, H +4 more
core
Deposition of diazepam and its metabolites in hair following a single dose of diazepam
, 2017 Only sporadic data are available on hair concentrations of diazepam and some of its metabolites (nordazepam, oxazepam, and temazepam) following a single controlled dose.
Linnet, Kristian +6 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh +3 more
wiley +1 more source
Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo
Frontiers in Pharmacology, 2020 BackgroundDiazepam is a benzodiazepine drug used to treat anxiety, insomnia, and muscle spasms. Imperatorin is a phytochemical isolated from medicinal plants and is widely used in herbal medicine. The aim of this study was to investigate the interactions
Yunfang Zhou +12 more
doaj +1 more source
Peak height ratio (PHR) of diazepam: diazepam -d5 (n = 3).
, 2014 Peak height ratio (PHR) of diazepam: diazepam -d5 (n = 3).
Sarah D. Sharratt (524628) +2 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective Seizure clusters, intermittent increases in seizure activity that differ from a patient's usual seizure pattern, may occur despite treatment with a daily anti‐seizure medication. Benzodiazepine‐containing immediate‐use seizure medications (ISMs; also called rescue therapies) are the cornerstone of treatment for seizure clusters ...
James W. Wheless +8 more
wiley +1 more source
Use of Diazepam to Correct Hemodynamic Changes in Explosive Mine Injury: Experimental Study
Общая реаниматология, 2007 Objective. To study the hemodynamic effect of benzodiazepine tranquilizers in explosive mine injury in an experiment.Materials and methods. The study was performed on non-inbred male rats; hemodynamic parameters were examined at the systemic, organ, and ...
V. N. Yelsky +2 more
doaj +1 more source
Diazepam-like effects of medicinal plants: A possible approach or a complementary method
, 2014 Since the introduction of diazepam (DZP) by Sternbach in the 1950s, few drugs acting on GABA receptors that do not belong to the class of benzodiazepines have been introduced in therapy. DZP is one of the most prescribed drugs in clinical practice; there
Costa, C. A.R.A. [UNESP] +1 more
core
Diazepam decreases leukocyte-endothelium interactions in situ
, 2010 High doses of diazepam reduce the inflammatory paw edema in rats. This effect was attributed to an action of diazepam on the Translocator Protein (TSPO).
SAKAI, M. +3 more
core +1 more source