Results 71 to 80 of about 100,754 (275)

Analysis and clinical findings of cases positive for the novel synthetic cannabinoid receptor agonist MDMB-CHMICA [PDF]

open access: yes, 2016
Context: MDMB-CHMICA is a synthetic cannabinoid receptor agonist which has caused concern due to its presence in cases of adverse reaction and death. Method: 43 cases of suspected synthetic cannabinoid ingestion were identified from patients presenting ...
Lowe, David J.   +5 more
core   +1 more source

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall   +3 more
wiley   +1 more source

Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice

open access: yesBrazilian Journal of Medical and Biological Research, 2000
The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic benzodiazepine, were examined in mice.
M.A. Rubin   +7 more
doaj   +1 more source

CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low‐gamma oscillations and seizure susceptibility

open access: yesEpilepsia, EarlyView.
Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh   +3 more
wiley   +1 more source

IV Valproate in Refractory Status Epilepticus

open access: yesPediatric Neurology Briefs, 2000
The results of treatment of refractory status epilepticus (SE) with IV valproate (VPA) in 41 children are reported from University Hospital for Children, Erlangen, Germany.
J Gordon Millichap
doaj   +1 more source

Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil   +4 more
wiley   +1 more source

Massive Carbamazepine Poisoning

open access: yesPediatric Neurology Briefs, 1993
The clinical features in 28 consecutive adult cases of laboratory confirmed massive overdosage with CBZ alone treated in an intensive care unit during the period 1981-1991 are reported from Southern Hospital, Karolinska Institute, Stockholm, Sweden.
J Gordon Millichap
doaj   +1 more source

Simultaneous pyometra and viable puppies’ gestation in a bitch [PDF]

open access: yes, 2014
Here we describe a case of pyometra coexisting with gestation in a 4.5 year-old miniature short-haired Dachshund. The dog exhibited depression, vaginal discharge, polydipsia and dehydration. Ultrasound examination revealed the presence of low to moderate
Corrada, Yanina Alejandra   +2 more
core   +5 more sources

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Lorazepam V Diazepam in Status Epilepticus

open access: yesPediatric Neurology Briefs, 1995
A prospective, open, odd and even dates trial of lorazepam compared to diazepam for the treatment of acute convulsions and status epilepticus in 102 children is reported from the Royal Liverpool Children’s NHS Trust, UK.
J Gordon Millichap
doaj   +1 more source

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