Results 211 to 220 of about 131,739 (305)

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Factors Associated With Concurrent Benzodiazepine and Opioid Use Following Total Hip and Knee Arthroplasty: A Nationwide Cohort Study. [PDF]

Pharmacoepidemiol Drug Saf
Yepes-Calderón M, Nelissen RGHH, Bouvy ML, van Steenbergen LN, Dahan A, Rosendaal FR, Gademan MGJ.   +6 more
europepmc   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Pharmacist-Led Taper with Brief Mindfulness-Informed Cognitive Behavioral Therapy for Benzodiazepine Deprescribing in Older Adults: A Pilot Trial. [PDF]

J Gen Intern Med
Anderson TS, Kraemer KM, McCann ML, Wang BX, Lindenberg JH, Yeh GY.   +5 more
europepmc   +1 more source

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source

United States healthcare encounters for poisoning involving cannabis relative to other substances. [PDF]

Am J Drug Alcohol Abuse
Conrad SW, Greene CR, Dal Pan G, Callahan CL, Meyer TE, Radin RG.   +5 more
europepmc   +1 more source

De‐Implementing Low‐Value Care in Dentistry: The Case for Choosing Wisely Campaigns

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT De‐implementation refers to the practice within implementation science that targets reducing low‐value care; that is practices that have been proven to be outdated, unnecessary, potentially harmful and in some cases not cost‐efficient. Reducing and removing habitual practices, as well as introducing new care, is not easy, as there are multiple
Fabio Arriola‐Pacheco, Rafael Aiello Bomfim, Karen Born, Herenia P. Lawrence   +3 more
wiley   +1 more source

A Pharmacist Consultant Service for Deprescribing Opioids and Benzodiazepines in Older Adults: A Cluster Randomized Trial.

JAMA Netw Open
Busby-Whitehead J, Ferreri SP, Niznik J, Armistead LT, Hughes T, Zhao L, Urick BY, Preisser JS, Larson C, Roberts E, Foushee L, Haddad Y.   +11 more
europepmc   +1 more source

Non-Catalyzed Cascade Double Imination Reaction of 2‑Fluoro-alk-3-yn-1-ones: Sustainable Synthesis of 3‑Fluoro-1,5-benzodiazepines. [PDF]

ACS Org Inorg Au
Olson TL, Kaspi-Kaneti AW, Zając A, Agyei Gyimah D, Walsh A, Weston JA, Rusakov AA, Wheeler KA, Török B, Dembinski R.   +9 more
europepmc   +1 more source

Distinct clinical clusters of paediatric patients with status epilepticus: Retrospective cohort study

Developmental Medicine &Child Neurology, EarlyView.
Large Swiss cohort of paediatric status epilepticus demonstrates that treatment delay (> 60 min) directly contributes to morbidity. Machine‐learning analysis of routine clinical data identifies three distinct patient clusters: febrile status epilepticus, severe para‐infectious status epilepticus, and status epilepticus in children with known epilepsy ...
Richard J Burman, Anne Steinberg, Jamie Norris, Giorgio Selmin, Tommaso Fedele, Richard E Rosch, Georgia Ramantani   +6 more
wiley   +1 more source