Results 251 to 260 of about 131,739 (305)
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Advances in Alcohol & Substance Abuse, 1990
The benzodiazepines were first introduced in 1960. Chlordiazepoxide (Librium) was the first of the class of drugs called benzodiazepines, in a deliberate attempt to synthesize a tranquilizer without the sedative properties and abuse, addiction, tolerance, and dependence potential of the barbiturates, and other sedative/hypnotic drugs. The popularity of
N S, Miller, M S, Gold
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The benzodiazepines were first introduced in 1960. Chlordiazepoxide (Librium) was the first of the class of drugs called benzodiazepines, in a deliberate attempt to synthesize a tranquilizer without the sedative properties and abuse, addiction, tolerance, and dependence potential of the barbiturates, and other sedative/hypnotic drugs. The popularity of
N S, Miller, M S, Gold
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British Journal of Addiction, 1981
SummaryBenzodiazepines, the most widely used of all drugs, are powerful anxiolytics, anticonvulsants and muscle relaxants. Dependence is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but do not provide a proper epidemiological ...
H, Petursson, M H, Lader
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SummaryBenzodiazepines, the most widely used of all drugs, are powerful anxiolytics, anticonvulsants and muscle relaxants. Dependence is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but do not provide a proper epidemiological ...
H, Petursson, M H, Lader
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Journal of Affective Disorders, 1987
Benzodiazepines (BDPs) are widely used drugs that are effective in controlling the symptoms of anxiety. Tolerance develops rapidly to some of the effects but not to anxiolytic effect in most patients. Dependence occurs at usual therapeutic doses and in a small proportion of patients is accompanied by an enormous increase in the dose taken. The majority
R P, Swinson, J C, Pecknold, M E, Kirby
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Benzodiazepines (BDPs) are widely used drugs that are effective in controlling the symptoms of anxiety. Tolerance develops rapidly to some of the effects but not to anxiolytic effect in most patients. Dependence occurs at usual therapeutic doses and in a small proportion of patients is accompanied by an enormous increase in the dose taken. The majority
R P, Swinson, J C, Pecknold, M E, Kirby
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International Anesthesiology Clinics, 1988
The structure of the GABAA receptor, through which GABA--the main inhibitory neurotransmitter in the mammalian CNS--produces its major synaptic effects, has recently been identified. The GABAA receptor is a member of a family of receptor-operated ion channels to which the nicotinic cholinergic receptor-cation channel and the glycine receptor-anion ...
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The structure of the GABAA receptor, through which GABA--the main inhibitory neurotransmitter in the mammalian CNS--produces its major synaptic effects, has recently been identified. The GABAA receptor is a member of a family of receptor-operated ion channels to which the nicotinic cholinergic receptor-cation channel and the glycine receptor-anion ...
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Anaesthesia, 1983
It appeared recently that the important group of psychoactive drugs, the benzodiazepines, binds with high affinity to a single class of saturable sites on brain membranes of all higher vertebrates including man. There was a good correlation between the pharmacological effects of different benzodiazepines and their affinity for 3H-diazepam and 3H ...
C, Braestrup, M, Nielsen
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It appeared recently that the important group of psychoactive drugs, the benzodiazepines, binds with high affinity to a single class of saturable sites on brain membranes of all higher vertebrates including man. There was a good correlation between the pharmacological effects of different benzodiazepines and their affinity for 3H-diazepam and 3H ...
C, Braestrup, M, Nielsen
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984
Dependence to benzodiazepines is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but provide no proper epidemiological framework for the estimation of risk.
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Dependence to benzodiazepines is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but provide no proper epidemiological framework for the estimation of risk.
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The American Journal of Drug and Alcohol Abuse, 1991
Two cases of intranasal benzodiazepine use are presented. The methods of preparation and administration of the powder and accounts of the pharmacological effects of the drugs used are described. The pattern of development and progress of the habit and its associated features are delineated.
M F, Sheehan +4 more
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Two cases of intranasal benzodiazepine use are presented. The methods of preparation and administration of the powder and accounts of the pharmacological effects of the drugs used are described. The pattern of development and progress of the habit and its associated features are delineated.
M F, Sheehan +4 more
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British Journal of Addiction, 1991
AbstractBenzodiazepines present problems related to both unwanted and withdrawal effects. Dosage adjustments usually obviate unwanted effects except for paradoxical reactions such as hostility. Patients with apparent benzodiazepine dependence need careful assessment with respect to personality, social situation and psychiatric disorder.
M, Lader, S, Morton
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AbstractBenzodiazepines present problems related to both unwanted and withdrawal effects. Dosage adjustments usually obviate unwanted effects except for paradoxical reactions such as hostility. Patients with apparent benzodiazepine dependence need careful assessment with respect to personality, social situation and psychiatric disorder.
M, Lader, S, Morton
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2015
Benzodiazepines have been in clinical use since the 1960s. Benzodiazepines act through allosteric modulation of the GABAA receptor to enhance the activity of GABA, an inhibitory neurotransmitter, resulting in a slowing of neurotransmission and sedative and anxiolytic effects.
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Benzodiazepines have been in clinical use since the 1960s. Benzodiazepines act through allosteric modulation of the GABAA receptor to enhance the activity of GABA, an inhibitory neurotransmitter, resulting in a slowing of neurotransmission and sedative and anxiolytic effects.
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Prior Benzodiazepine Exposure and Benzodiazepine Treatment Outcome
The Journal of Clinical Psychiatry, 2000We examined discontinuation symptoms following brief benzodiazepine therapy (8 weeks) and intermittent benzodiazepine therapy (2 weeks with at least 2 weeks without drug) and associations with prior benzodiazepine use. The hypothesis was that prior benzodiazepine use would predispose patients to more severe discontinuation symptoms.Data were drawn from
K, Rickels, E W, Freeman
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