Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. [PDF]
, 2015 Ligand efficiency has proven to be a valuable concept for optimization of leads in the early stages of drug design. Taking this one step further, group efficiency (GE) evaluates the binding efficiency of each appendage of a molecule, further fine-tuning ...
Abrahams +19 more
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A Simple Approach to Distinguish Classic and Formaldehyde-Free Tannin Based Rigid Foams by ATR FT-IR [PDF]
, 2015 Tannin based rigid foams (TBRFs) have been produced with formaldehyde since 1994. Only recently several methods have been developed in order to produce these foams without using formaldehyde.
Alexander, Petutschnigg +3 more
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MoleculesAn efficient cascade cyclization strategy was developed to synthesize aminobenzofuran spiroindanone and spirobarbituric acid derivatives utilizing 2-bromo-1,3-indandione, 5-bromo-1,3-dimethylbarbituric acid, and ortho-hydroxy α-aminosulfones as ...
Rong-Rong Zhu, Xi-Qiang Hou, Da-Ming Du
doaj +1 more source
Chemo-enzymatic synthesis of new resveratrol-related dimers containing the benzo[b]furan framework and evaluation of their radical scavenger activities [PDF]
, 2015 The chemo-enzymatic synthesis and the evaluation of radical scavenger performance of resveratrolrelated dimers with antioxidative power have been investigated.
Beneventi, Elisa +4 more
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2-(5-Methyl-1-benzofuran-3-yl)-N-(2-phenylethyl)acetamide
IUCrData, 2017 The title compound, C19H19NO2, is non-planar with the phenyl ring of the phenethylacetamide residue inclined to the benzofuran ring system by 84.8 (3)°. The methyl group lies in the plane of the fused ring system [C—C—C—C torsion angle = −179.6 (3)°]. In
N. Ramprasad +5 more
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Synthesis and 2D-QSAR Study of Active Benzofuran-Based Vasodilators
Molecules, 2017 A new series of 2-alkyloxy-pyridine-3-carbonitrile-benzofuran hybrids (4a–x) was synthesized. All the new derivatives were examined via the standard technique for their vasodilation activity.
Nagy M. Khalifa +4 more
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Journal of Taibah University for Science, 2019 The ever-increasing spread of bacterial infection with rising antibacterial drug resistance has become a matter of global concern in the modern times. Therefore, such serious infections leading to high mortality rate has necessitated the search for new ...
Bhushan Nazirkar +2 more
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Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors
Beilstein Journal of Organic Chemistry, 2017 Novel 13α-estrone derivatives were synthesized by Sonogashira coupling. Transformations of 2- or 4-iodo regioisomers of 13α-estrone and its 3-methyl ether were carried out under different conditions in a microwave reactor. The 2-iodo isomers were reacted
Ildikó Bacsa +6 more
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Metabolic fate, mass spectral fragmentation, detectability, and differentiation in urine of the benzofuran designer drugs 6-APB and 6-MAPB in comparison to their 5-isomers using GC-MS and LC-(HR)-MSn techniques [PDF]
The number of so-called new psychoactive substances (NPS) is still increasing by modification of the chemical structure of known (scheduled) drugs. As analogues of amphetamines, 2-aminopropyl-benzofurans were sold.
A Stanczuk +29 more
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, 2004 While quantum information processing by nuclear magnetic resonance (NMR) with small number of qubits is well established, implementation of lengthy computations have proved to be difficult due to decoherence/relaxation.
Das, Ranabir, Gopinath, T., Kumar, Anil
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