Results 61 to 70 of about 3,645 (198)

Grupos protectores fotocliváveis para aminoácidos e péptidos [PDF]

, 2005
Tese de mestrado em Química, especialização em Ensino.O objectivo primário deste trabalho consistiu na síntese de novos derivados de heterociclos de oxigénio, os ácidos nafto[2,1-b]furan-1-il etanóicos e os 1-clorometil-3- oxo-3H-benzo[f]benzopiranos e
Piloto, Ana M.
core  

Identification of distant drug off-targets by direct superposition of binding pocket surfaces. [PDF]

, 2013
Correctly predicting off-targets for a given molecular structure, which would have the ability to bind a large range of ligands, is both particularly difficult and important if they share no significant sequence or fold similarity with the respective ...
Armen, Roger S, Schumann, Marcel
core   +4 more sources

Chromones as Nonclassical Inhibitors of Carbonic Anhydrase IX and XII Isoforms: Probing Chromone‐Based Derivatives

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
Chromone‐based derivatives were synthesized and evaluated for selective inhibition of tumor‐associated carbonic anhydrases IX and XII. Structure–activity relationships, docking studies, and ADMET profiling revealed promising candidates with selective tumoral isoform inhibition, supporting their potential as anticancer leads. ABSTRACT A small library of
Lisa Sequeira, Simona Distinto, Carlos Fernandes, Erica Sanna, Rita Meleddu, Marco Gaspari, Filippo Cottiglia, Alessia Onali, Andrea Angeli, Fernanda Borges, Eugenio Uriarte, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni   +13 more
wiley   +1 more source

Phytochemicals and Anti-Inflammatory Activity of Melicope Ptelefolia Champ Ex Benth [PDF]

, 2005
Leaves of Melicope ptelefolia Champ ex Benth were examined for phytochemicals. Using various chromatography techniques such as normal column chromatography, gel filtration on sephadex LH-20 and radial chromatography seven compounds were isolated ...
Suryati,
core  

Propolis‐Based Hybrid Nanoflowers as Multifunctional Nanozymes: Structural Integration of Polyphenols for Enhanced Catalytic and Antioxidant Activity

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT Propolis is a polyphenol‐rich natural resin with well‐documented antioxidant activity; however, its practical application is restricted by poor aqueous solubility and limited stability. Herein, propolis‐based organic–inorganic hybrid nanoflowers (Prp‐Nfs) were synthesized by integrating a propolis extract into a Cu3(PO4)2·3H2O matrix under ...
Cevahir Altinkaynak, Fatih Kirmizikar
wiley   +1 more source

Photolysis at long wavelengths of amino acid ester derivatives based on 4-methyl-6-methoxy-2-oxo-2H-naphtho[1,2-b]pyrans [PDF]

, 2011
Ester derivatives of fused 4-methyl-6-methoxy-2-oxo-2H- naphtho[1,2-b]pyran, using valine and phenylalanine as model bifunctional molecules were synthesised, to assess its applicability as a photocleavable protecting group, for solution phase organic ...
Costa, Susana P. G., Gonçalves, M. Sameiro T., Hungerford, Graham, Piloto, Ana M., Soares, Ana M. S.   +4 more
core  

Graphene Oxide-Supported Oxime Palladacycles as Efficient Catalysts for the Suzuki–Miyaura Cross-Coupling Reaction of Aryl Bromides at Room Temperature under Aqueous Conditions [PDF]

, 2017
Palladacycles are highly efficient precatalysts in cross-coupling reactions whose immobilization on carbonaceous materials has been hardly studied.
Alonso, Diego A., Baeza, Alejandro, Gómez-Martínez, Melania   +2 more
core   +2 more sources

Synthesis of Isochromans From Anacardic Acids Obtained From Cashew Nutshell Liquid (CNSL) and Their Antimicrobial Activity

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Utilizing anacardic acid derived from cashew nut shell liquid, the synthesis of isochromans was accomplished. Two key steps were exploited. Firstly, a benzylic bromination in the green solvent tert‐butyl acetate is disclosed. Secondly, as an example, the exposure of the secondary alcohol 1‐(2‐methoxy‐6‐(pentadec‐1‐en‐1‐yl)phenyl)ethanol to potassium t ...
Bianca L. Davids, Tianqi Lu, Kennedy J. Ngwira, Manuel A. Fernandes, Sandy van Vuuren, Charles B. de Koning   +5 more
wiley   +1 more source

Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen. [PDF]

, 2016
Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or ...
Arur, Benard, Benzie, Bird, Bubols, Burgon, d'Alencon, Dalli, Edwards, Edwards, Elks, Ellett, Ferguson, Fougerousse, Fox, Hall, Hall, Hannigan, Haslett, Heasman, Henry, Hirao, Hirsch, Holmes, Jenkins, Kleiner, Liles, Loynes, Lucas, Mathias, Medzhitov, Mouysset, Niethammer, Niwa, North, Nusslein-Volhard, Pirkle, Pongracz, Prajsnar, Prince, Renshaw, Rieger, Robertson, Savill, Scannell, Schepetkin, Serhan, Takaki, Tamplin, Trede, Tyas, Vago, Vlahos, Wang, Xia, Yabu, Yang, Yazid, Yazid, Yoo   +59 more
core   +4 more sources

Isolation, RP‐UHPLC‐ESI‐LIT‐Orbitrap‐MS/MS‐Based Metabolic Profiling and Anticandidal Activity of the Root and Leaf Secondary Metabolites of Monotes Kerstingii Gilg (Dipterocarpaceae)

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
This paper describes the isolation and antifungal activity of secondary metabolites from the leaves and roots of Monotes kerstingii. The distribution of these metabolites in the roots and leaves was achieved through comprehensive RP‐UHPLC‐Orbitrap‐MS and MS/MS analysis.
Sorelle Kache Fotsing, Dominique Ngnintedo, Yanick Kevin Dongmo Melogmo, Alena Soboleva, Kevine Dongmo Jumeta, Bruno Ndjakou Lenta, Fabrice Fekam Boyom, Andrej Frolov, Norbert Arnold, Ludger A. Wessjohann, Norbert Sewald, Bonaventure Tchaleu Ngadjui, Ghislain Wabo Fotso   +12 more
wiley   +1 more source