Results 61 to 70 of about 10,026 (250)

Theoretical Study of Intermolecular Interactions in Benzopyrans Substituted with Polyhaloalkyl Groups

open access: yesChemistry Proceedings
A study of the solid-state intermolecular interactions of twenty-nine benzopyrans substituted with polyhaloalkyl groups was carried out by quantum chemical calculations using the Mercury and WinGX computer programs.
Lissette A. Haro-Saltos   +2 more
doaj   +1 more source

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain

open access: yesPharmaceuticals, 2014
Sharpless asymmetric dihydroxylation of styrene derivative 6 afforded chiral triols (R)-7 and (S)-7, which were cyclized with tosyl chloride in the presence of Bu2SnO to provide 2-benzopyrans (R)-4 and (S)-4 with high regioselectivity.
Katharina Holl   +8 more
doaj   +1 more source

Metabolomics of Eryngium heterophyllum by UHPLC‐QToF‐MS and In Silico Insights Into Potential Metabolic Syndrome Targets

open access: yesChemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Eryngium heterophyllum has 85 metabolites according to nontargeted UHPLC‐QTOF‐MS profiling, with flavonoids and phenylpropionic acids emerging as significantly related bioactive families. In silico compound–disease–target networks connect 31 metabolites to inflammation, diabetes, obesity, and cardiovascular disease associated with metabolic syndrome ...
Citlaly Gutiérrez‐Rodelo   +5 more
wiley   +1 more source

Photochemical studies on 3,4-epoxy-3,4-dihydro-2H-1-benzopyrans

open access: yes, 1992
Photochemical behaviour of 3,4-epoxy-3,4-dihydro-2H-1-benzopyrans, intermediates in the synthesis of pterocarpans, has been studied in various solvents.
Balasubramanian, K. K.   +2 more
core   +1 more source

Regio- and Diastereoselective Insertion of Allenes into Stable Oxapalladacycles with a Metal-Bonded Stereogenic Carbon. Preparation of Contiguously Substituted 3,4-Dihydro-2H-1-Benzopyrans

open access: yes, 2016
Insertion of monosubstituted allenes into stable oxapalladacycle I was studied. The aim of this work was to define steric and electronic parameters of allenes that would allow for a regio- and diastereoselective synthesis of 2,3-disubstituted 3,4-dihydro-
Helena C. Malinakova (1915663)   +1 more
core   +2 more sources

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

open access: yesDrug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq   +6 more
wiley   +1 more source

The Exploration of Natural Compounds for Anti-Diabetes from Distinctive Species Garcinia linii with Comprehensive Review of the Garcinia Family

open access: yesBiomolecules, 2019
Approximately 400 Garcinia species are distributed around the world. Previous studies have reported the extracts from bark, seed, fruits, peels, leaves, and stems of Garcinia mangostana, G. xanthochymus, and G.
Ting-Hsu Chen   +3 more
doaj   +1 more source

Efficacy and Tolerability of Tegoprazan Compared to Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

open access: yesJGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Aim Tegoprazan, a potassium‐competitive acid blocker, is an acid‐suppressing medication under review as a potential alternative treatment in cases of erosive esophagitis. This systematic review and meta‐analysis assesses the efficacy and tolerability of tegoprazan compared to proton pump inhibitors, the current standard of care. Methods Pubmed,
Youssef Diab   +6 more
wiley   +1 more source

Effect of molecular perturbation on cocrystal formation: theophylline and its 8‐halo analogues with flavonoids

open access: yesActa Crystallographica Section C, Volume 82, Issue 8, Page 414-426, August 2026.
The tendency for alkaloid–flavonoid cocrystal formation is found to be markedly different for theophylline (Tph) compared to its 8‐halo analogues. Through screening with 13 common flavonoids, Tph is found to form cocrystals with six flavonoids, whereas 8‐Cl‐Tph and 8‐Br‐Tph each form cocrystals with just two, myricetin and kaempferol.
Weijian Ye   +2 more
wiley   +1 more source

Synthesis of Benzopyran Atropisomers via Electrophilic Halogenation

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
We report a halogenation‐based method for the synthesis of axially chiral benzopyrans, tolerating diverse substituents and halogens (Br, Cl, and I). A double bromination gives bisbenzopyrans with two stereogenic axes. Preliminary enantioselective conditions yield benzopyran atropisomer with up to 56% ee.
Alix Bourhis   +3 more
wiley   +1 more source

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