Results 141 to 150 of about 1,130 (187)
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BENZYLISOQUINOLINE STUDIES. PART I. OPEN-RING MODELS OF 4-BENZYLISOQUINOLINES
Journal of Organic Chemistry, 1950exaly +2 more sources
The microbial oxygenation of the benzylisoquinoline alkaloid laudanosine
Experientia, 1983The microbial transformation of the benzylisoquinoline alkaloid laudanosine by a strain of Pseudomonas putida gives a metabolite in which O-demethylation of 1 methoxyl group of ring C, and introduction of 1 ketonic oxygen at C9 and 1 phenolic oxygen at ring C have occurred. Also, O-methylcoripalline is formed in this transformation.
L, Canonica +5 more
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Microbial Factories for the Production of Benzylisoquinoline Alkaloids
Trends in Biotechnology, 2016Benzylisoquinoline alkaloids (BIAs) are a family of ∼2500 alkaloids with both potential and realized pharmaceutical value, including most notably the opiates such as codeine and morphine. Only a few BIAs accumulate readily in plants, which limits the pharmaceutical potential of the family.
Lauren, Narcross +4 more
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A polarographic investigation of benzylisoquinoline alkaloids
Chemistry of Natural Compounds, 19771. The polarographic behavior of six benzoisoquinoline alkaloids has been investigated. In the reduction of thalfine, thalsimine, and thalsimidine the products of the electrode reactions are the corresponding tetrahydro derivatives.
E. K. Dobronravova +2 more
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ChemInform, 1989
AbstractIn the course of attempts to prepare analogous derivatives of (I) and (II), some procedures previously employed for the derivatization of papaverine (I) turn out to be unsuccessful in the case of (II).
C. VACCHER +5 more
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AbstractIn the course of attempts to prepare analogous derivatives of (I) and (II), some procedures previously employed for the derivatization of papaverine (I) turn out to be unsuccessful in the case of (II).
C. VACCHER +5 more
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Opium Alkaloids X: Biosynthesis of 1-Benzylisoquinolines
Journal of Pharmaceutical Sciences, 1971Radioactively labeled norreticuline was incorporated into papaverine in Papaver somniferum to an extent of about 5% without prior demethylation to norlaudanosoline. 1,2-Dehydronorreticuline does not participate in the biosynthesis of this alkaloid. (+)-Laudanosine is derived from (+)-reticuline via (+)-laudanidine, while (+)-codamine plays only a minor
E, Brochmann-Hanssen +3 more
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A New Benzylisoquinoline Alkaloid:N-Methylpalaudinium Chloride
Journal of Pharmaceutical Sciences, 1972A new benzylisoquinoline alkaloid, N-methylpalaudinium chloride (I), was isolated from Thalictrum polygamum Muhl. (Ranunculaceae).
M, Shamma, J L, Moniot
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Evolution of Benzylisoquinolines in Magnoliiflorae
1982Phenylalanine, through benzyltetrahydroisoquinoline (BTIQ) intermediates, is responsible for the biosynthesis of three alkaloidal types headed by aporphines (skeleta prefixed 11–19), berberines (21) and morphines (31–34), the benzylisoquinoline (BIQ) biogenetic group of alkaloids.
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Structure-antioxidative activity relationships in benzylisoquinoline alkaloids
Pharmacological Research, 1995The antioxidative properties of the aporphines boldine, glaucine and apomorphine, and of the benzyltetrahydroisoquinolines (+/-)-coclaurine and (+/-)-norarmepavine were compared in the brain homogenate autoxidation model. The IC50 values found lay in the 16-20 microM range for the aporphines and were 131.7 microM, and 79.3 microM for coclaurine and ...
Cassels Niven, Bruce +5 more
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Isoquinoline and Benzylisoquinoline Alkaloids
1998Alkaloids that possess an isoquinoline moiety in their structure are among the most common of all alkaloids. More than 4000 compounds of many structural types but with this structural feature are known (Verpoorte et al., 1991). Those treated in this chapter are all derived from a 3,4-dihydroxytyramine (dopamine) precursor that is linked to an aldehyde ...
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