Results 101 to 110 of about 2,312,058 (282)

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

MAP17 Enhances Chemoresistance and Tumorigenicity of Glioblastoma‐Initiating Cells via the Canonical NF‐кB Pathway

Cancer Science, EarlyView.
MAP 17 is identified as highly expressed in TMZ‐resistant glioblastoma‐initiating cells (GICs). MAP17 enhances GIC proliferation, TMZ resistance, and tumorigenicity through NF‐κB/RELA‐dependent BCL2 upregulation. ABSTRACT Glioblastoma (GBM) is the most common malignant brain tumor in adults.
Shenshen Dou, You Lee Son, Toru Kondo
wiley   +1 more source

Constructed value of information with iterative scoring and parametric uncertainty to identify management‐relevant research priorities for a declining raptor species

Conservation Biology, EarlyView.
Abstract Constructed value of information (CVoI) is an expert elicitation decision‐analytic tool used to prioritize sources of uncertainty based on their potential to improve decision outcomes if resolved. Despite increased application of CVoI, the robustness of CVoI prioritization of sources of uncertainty relative to differences in expert elicitation
Kristin P. Davis, Mitchell J. Eaton, Emily R. Bjerre, Hillary M. White, Clint W. Boal, Jennifer H. Herner‐Thogmartin, Orin J. Robinson, Abigail J. Lawson   +7 more
wiley   +1 more source

Rare Secondary Neoplasms Arising in Epidermal Nevus: A Case Series and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Malignant transformation is known to occur with many nevi, such as nevus sebaceus. However, cases of secondary tumors developing in an epidermal nevus (EN) are rare, with only a few case reports documented in the literature. We present three unique cases of syringocystadenoma papilliferum (SCAP), syringofibroadenoma, trichilemmoma, and basal ...
Haya A. Homsi, Melissa Piliang, Jennifer Lucas, Jennifer S. Ko, Steven D. Billings, Shira Ronen   +5 more
wiley   +1 more source

Estimating the probability of messages delivery in an IoT system

Вестник Дагестанского государственного технического университета: Технические науки
Objective. The aim of the study is to develop a model for estimating the probability of message delivery in a medical Internet of Things (IoMT) system and to study the dependence of this value on the number of retransmissions used to compensate for ...
K. A. Polshchykov, T. N. Mahdi
doaj   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Anthromes and terrestrial carbon

PLANTS, PEOPLE, PLANET, EarlyView.
Anthony P. Walker, Rose Z. Abramoff, Kathryn Baragwanath, Matthew E. Craig, Yadvinder Malhi, Crystal N. H. McMichael   +5 more
wiley   +1 more source

Immunophenotypic assessment of pure embryonal carcinoma and yolk sac tumour suggests that reprogramming to non‐seminoma occurs outside the spermatogonial niche

Histopathology, EarlyView.
Immunohistochemical analysis of transcription factors in GCNIS associated with pure EC and YST suggests that reprogramming to non‐seminoma occurs outside the spermatogonial niche. In these tumors, reprogramming may occur immediately upon invasion of the stroma or within seminiferous tubules but outside the spermatogonial niche (i.e., in intratubular ...
Daisy Maharjan, Květoslava Michalová, Joao Lobo, Jennifer Gordetsky, Fiona MacLean, Ankur R Sangoi, Daniel Berney, Chia‐Sui Kao, Costantino Ricci, Adeboye O Osunkoya, Maria Rosaria Raspollini, Geert JLH van Leenders, Muhammad T Idrees, Lee Ann Baldridge, Thomas M Ulbright, Andres M Acosta   +15 more
wiley   +1 more source

The method of high-speed digital data transfer over unsteady optic channel with using M-ary amplitude-shift keying for phased array antenna radar stations

Известия высших учебных заведений России: Радиоэлектроника, 2015
The problem of high-speed digital data transfer from a phased array antenna receiving module to the digital signal processing module with using domestically produced circuitry is concerned. The method of information transfer over nonlinear unsteady optic
A. I. Belyaev, A. V. Myakinkov
doaj  

The DDMRP Replenishment Model: An Assessment by Simulation

Mathematics
Demand-Driven Material Requirements Planning (DDMRP) has been proposed as a solution for managing uncertainty and variability in supply chains by combining decoupling, buffer management and demand-driven planning principles. A key element of DDMRP is its
Nuno O. Fernandes, Suleimane Djabi, Matthias Thürer, Paulo Ávila, Luís Pinto Ferreira, Sílvio Carmo-Silva   +5 more
doaj   +1 more source