Results 51 to 60 of about 2,388 (160)

Phenanthrene Alkaloids From Guatteria Olivacea as Topoisomerase II Inhibitors: Theoretical Insights and Cytotoxic Evaluation

ChemistrySelect, Volume 11, Issue 2, 15 January 2026.
Three phenanthrene alkaloids from Guatteria olivacea were studied by DFT, docking, MD, and cytotoxicity assays. All compounds showed stable binding to DNA–topoisomerase II and human serum albumin. Atherosperminine exhibited cytotoxic activity against four cancer cell lines, supporting its potential as a topoisomerase II inhibitor and anticancer ...
Renyer A. Costa, Victor L. Tananta, Ianni de O. Corrêa, Jamelah S. Al‐Otaibi, Y. Sheena Mary, Milena Botelho P. Soares, Daniel P. Bezzera, Morgana de S. Araújo, Emmanoel V. Costa   +8 more
wiley   +1 more source

Modified Guizhi Plus Huangqi Decoction Improves Antiphospholipase A2 Receptor Antibody–Induced Podocyte Injury Through Modulating Autophagy‐Related Markers via AMPK/mTOR Pathway

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) is a primary cause of nephrotic syndrome in adults. Modified Guizhi plus Huangqi decoction (MGPHD) has been clinically effective for PLA2R MN. This basic study was designed to investigate the efficacy and mechanisms of MGPHD in treating PLA2R MN.
Manxia Huang, Yangpu Li, Zhishu Yang, Yunxin Lin, Zhuoting Liu, Zilan Jiang, Tingting Tan, Xinhui Liu, Youjia Zeng, Yue Xu   +9 more
wiley   +1 more source

Phytochemical study on Berberis sibirica Pall.

Mongolian Journal of Chemistry, 2014
From the aerial parts (700g) of berberis sibirica pall. 6 isoquinoline alkaloids of protoberberine, protopine, benzophenantridine and proaporphine type were isolated. The known alkaloids (-)-tetrahydropseudocoptisine, pseudoprotopine, (+)-chelidonine and
A Solongo, R Istatkova, S Philipov, S Javzan, D Selenge   +4 more
doaj   +1 more source

From Demyelination to Intervention: Natural Compounds as Emerging Therapeutic Targets in Multiple Sclerosis Neuroinflammation

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Multiple sclerosis (MS) is a chronic immune‐mediated inflammatory demyelinating disease of the central nervous system (CNS), characterized by multifocal lesions, axonal damage, and progressive neurological dysfunction, imposing a heavy burden on patients and healthcare systems.
Zhiyong Long, Qianyue Yang, Yonghe Wu, Lifei Wan, Liuting Zeng, Lingyun Sun, Poorani Gurumallesh   +6 more
wiley   +1 more source

Molecular Mechanisms of Anti‐Inflammatory and Immunomodulatory Activities of Key Phytochemicals: A Comprehensive Review

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Phytochemicals derived from medicinal plants represent a rich and largely underexploited source of anti‐inflammatory and immunomodulatory agents. Chronic inflammation and dysregulated immune responses underpin many tropical and global diseases, including infectious, autoimmune, and metabolic disorders. This review examines the spectrum of plant‐derived
Md Asaduzzaman, Lutfun Nahar, Mohammad Shahangir Biswas, Md. Matiar Rahman, Zhengwei Huang   +4 more
wiley   +1 more source

Berberine Alleviates Lipopolysaccharide‐Induced Impairments in Neuroplasticity and Spatial Memory by Modulating Microglial Polarization via MAPK Signaling Inhibition

Neural Plasticity, Volume 2026, Issue 1, 2026.
Neuroinflammation‐induced cognitive impairment is characterized by a continued decline in memory, executive functioning, and information‐processing abilities. Although berberine (BBR) exhibits anti‐inflammatory and neuroprotective properties, its ability to mitigate cognitive deficits by regulating microglial‐mediated neuroinflammation remains ...
Lirong Jiang, Ruiyi Liao, Jiaxin Wang, Yuan Yang, Jiaojiao Sun, Li Liu, Yiwei Wang, Wei Dong, Yang Yu, Fernando Peña-Ortega   +9 more
wiley   +1 more source

FAMILIA BERBERIDACEAE

Flora del Bajío y de Regiones Adyacentes, 2009
Familia con 10 a 15 géneros y más de 650 especies, distribuidas principalmente en las regiones templadas del Hemisferio Norte, desde Asia oriental hasta Norteamérica. En México solamente se presenta el género Berberis.
openaire   +1 more source

Enhancing Urban and Suburban Green Spaces: Dendrological Diversity and Climate Adaptation

The Scientific World Journal, Volume 2026, Issue 1, 2026.
This study presents the first integrated, multicity assessment of urban green infrastructure in Armenia, focusing on three major cities, Yerevan, Gyumri, and Vanadzor, that represent contrasting climatic conditions. The study combines an analysis of the present climatic conditions and green‐space structure with a long‐term assessment of dendrological ...
Zhirayr Hmayak Vardanyan, Janna Andranik Akopian, Maxim Viktorovich Larionov, Gayane Manuk Gatrchyan, Nelli Norik Muradyan, Sergey Artur Ktrakyan, Hovik Yakhshibek Sayadyan, Manik Meruzhan Grigoryan, Abreham Berta Aneseyee   +8 more
wiley   +1 more source

Gene Expression Omnibus database analysis reveals comorbidity mechanisms of type 2 diabetes mellitus and vascular dementia and predicts potential herbal therapeutics

Advanced Chinese Medicine, Volume 2, Issue 4, Page 147-162, December 2025.
Abstract Objective This study aimed to investigate the comorbid mechanisms linking type 2 diabetes mellitus (T2DM) and vascular dementia (VaD), focusing on the roles of astrocytes and neurons, and to identify potential therapeutic traditional Chinese medicines (TCMs) and compounds.
Meiyue Li, Xue Li, Lijia Xu, Peigen Xiao, Pei Ma, Lifeng Yue   +5 more
wiley   +1 more source

A Workflow for Selecting, Profiling, and Optimizing Plant Extracts for Cosmetic Applications

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT In response to the growing demand for innovative natural ingredients in cosmetics, this study proposes a structured approach to identifying bioactive plant species available in France. From 1614 species screened for regulatory acceptability and innovation potential, 18 were shortlisted for phytochemical profiling (high‐performance liquid ...
Maria Viéytez, Aline Robert‐Hazotte, Amélie Thomas, Véronique Nardello‐Rataj, Xavier Fernandez   +4 more
wiley   +1 more source