Results 211 to 220 of about 51,162 (293)

Monitoring of Nonacog Beta Pegol: One‐Stage Clotting Assay With Kaolin Reagent as a Practical Alternative to Chromogenic Methods

Haemophilia, EarlyView.
ABSTRACT Introduction Accurate monitoring of nonacog beta pegol (N9‐GP) is essential to ensure appropriate treatment and to avoid under‐ or overdosing, which may result in clinical complications. The product's extended half‐life, achieved through molecular modification, poses challenges for activity measurement, particularly when using a one‐stage ...
Marie Prudková, Petr Smejkal, Dagmar Chytrá, Jiřina Zavřelová, Gabriela Romanová, Miroslav Penka, Alena Buliková   +6 more
wiley   +1 more source

In Silico Assessment of Limited Blood Sampling Strategies for Individualised Pharmacokinetic‐guided Dosing of Efanesoctocog Alfa in Haemophilia A Patients

Haemophilia, EarlyView.
ABSTRACT Introduction Efanesoctocog alfa is a novel factor VIII (FVIII) concentrate with a unique molecular design that enables Von Willebrand Factor‐independent clearance in patients with haemophilia A. Limited sampling strategies (LSSs) are necessary to implement accurate pharmacokinetic (PK)‐guided dosing for efanesoctocog alfa in clinical practice.
Jelien den Hollander, Marjon H. Cnossen, Ron A. A. Mathôt   +2 more
wiley   +1 more source

Patient and Caregiver Preferences for Long‐Term Prophylactic Treatment of Bleeds in Haemophilia: A Discrete‐Choice Experiment

Haemophilia, EarlyView.
ABSTRACT Introduction The expansion of haemophilia treatment to include non‐factor prophylaxis provides new options with various benefits, risks, administration modes, and device types, necessitating trade‐offs in decision‐making. Aim This study evaluated prophylactic treatment preferences of people with haemophilia and their caregivers, assessing ...
Hui Lu, Travis Gould, Carmine Colavecchia, Joshua Coulter, Lisa J. Wilcox, Joseph C. Cappelleri, Stephanie A. Christopher, Alexis Sohn, Brett Hauber, Álvaro A. Gutiérrez‐Vargas, Nicola Dunn, Pratima Chowdary, Jennifer A. Whitty   +12 more
wiley   +1 more source

International Practices in Managing Preconception, Pregnancy and Childbirth in Women With Glanzmann Thrombasthenia: A Survey From the European Association of Haemophilia and Allied Disorders (EAHAD)

Haemophilia, EarlyView.
ABSTRACT Background Glanzmann thrombasthenia (GT) is an inherited platelet disorder resulting in severely reduced platelet aggregation and increased bleeding tendency. Pregnancy and childbirth in women with GT present significant challenges for both mother and child.
Karlijn H. G. Rutten, Roger E. G. Schutgens, Roseline d'Oiron, Mathieu Fiore, Giancarlo Castaman, Keith Gomez, Mary Mathias, Michelle Lavin, Petra Elfvinge, Rezan Abdul Kadir, Karin P. M. van Galen, the Glanzmann Thrombasthenia and Women and Girls with Bleeding Disorders Working Groups of the EAHAD   +11 more
wiley   +1 more source

Investigation of the Suitability of the ROTEM Assay to Measure Coagulation Potential in Blood From Patients on Concizumab Prophylaxis

Haemophilia, EarlyView.
ABSTRACT Background Rotational thromboelastometry (ROTEM) aims to measure the coagulation potential in whole blood. Concizumab, an anti‐tissue factor pathway inhibitor (TFPI) antibody for prophylaxis in haemophilia, enhances tissue factor (TF)‐initiated coagulation by preventing inhibition of activated factor X (FXa), thus increasing thrombin ...
Hermann Eichler, Nora V. Butta, Anne Riddell, Cecilia Augustsson, Marianne Kjalke, Kasper Jensen, Andrea Paramo‐Florencio, Jan Astermark, Pratima Chowdary, Victor Jiménez‐Yuste   +9 more
wiley   +1 more source

Prokaryotic Community Composition in Arctic Kongsfjorden and Sub-Arctic Northern Bering Sea Sediments As Revealed by 454 Pyrosequencing. [PDF]

Front Microbiol, 2017
Zeng YX, Yu Y, Li HR, Luo W.
europepmc   +1 more source

Supporting Patient‐Centred Decisions on Gene Therapy for Haemophilia A: A Conceptual Model

Haemophilia, EarlyView.
Giovanni Di Minno, Sarah Bigi, Serena Barello, Enrico Ferri Grazzi, Marco Follino, Maria Francesca Mansueto, Mariasanta Napolitano, Rita Carlotta Santoro, Giancarlo Castaman   +8 more
wiley   +1 more source

Sleep and Haemophilia–A Case‐Control Analysis of Associated Factors

Haemophilia, EarlyView.
ABSTRACT Introduction Sufficient sleep is essential for maintaining both physical and mental health, yet data on sleep health among persons with haemophilia (PwH) remain limited. Aim This study aimed to assess sleep in PwH compared to healthy controls (Con) and identify factors associated with impaired sleep quality (SQual) in PwH. Methods 100 PwH A or
Alexander Schmidt, Marius Brühl, Pia Möllers, Jamil Hmida, Fabian Tomschi, Joschua Wiese, Heinrich Richter, Jonas Roos, Thomas Hilberg, Andreas Christian Strauss   +9 more
wiley   +1 more source

Environmental predictors of ice seal presence in the Bering Sea. [PDF]

PLoS One, 2014
Miksis-Olds JL, Madden LE.
europepmc   +1 more source

Hemophilia Severity and Its Association With Mental Health and Health‐Related Quality of Life—Results From a Cross‐Sectional Multicenter Study

Haemophilia, EarlyView.
ABSTRACT Background Limited existing research on mental health and health‐related quality of life (HRQoL) in people with hemophilia (PwH) suggests these patients still may have poor mental health despite treatment advances significantly improving somatic outcomes.
Francesca Schmitt, Laura Maier, Stefan Lerch, Manuela Albisetti, Alice Trinchero, Lukas Graf, Heinz Hengartner, Pierre Fontana, Nicolas von der Weid, Katrin Scheinemann, Sylvia von Mackensen, Corinna Reichl, Marialuisa Cavelti, Ines Mürner‐Lavanchy, Johanna A. Kremer Hovinga, Michael Kaess, Mutlu Kartal‐Kaess   +16 more
wiley   +1 more source