Results 221 to 230 of about 179,183 (295)

High-Recall Biomedical Language Models for Radiation Oncology Evidence Synthesis: An Integrated Systematic Review of Prediction Models for Radiotherapy-Induced Complications in Nasopharyngeal Carcinoma. [PDF]

Life (Basel)
Lin GZ, Hsieh YW, Cheng CY, Wang CC, Chang L, Liu CH, Yun WP, Yeh SA, Wuu CS, Chiu CL, Chao PJ, Lee TF.   +11 more
europepmc   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Annals of Neurology, EarlyView.
Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified.
Ionuț‐Flavius Bratu, Isabelle Lambert, Olivier Felician, Samuel Medina Villalon, Agnès Trébuchon, Fabrice Bartolomei   +5 more
wiley   +1 more source

Enhancing Reaction Kinetics and Structural Control in N‐Carboxyanhydride (NCA) Polypeptide Synthesis by Structurally Tuned Azamacrocyclic Ligands

Angewandte Chemie, EarlyView.
Azamacrocycles provide a tunable platform for rapid N‐carboxyanhydride (NCA) Ring‐Opening Polymerization (ROP). Changing the methylation pattern switches the macrocycle from an external catalyst (N14Me3) to a covalent initiator‐catalyst (IniCat, N14Me1), delivering controlled polypeptide growth under open‐vessel conditions.
Paulina Maksym, Adam Gorczynski, Robert D. Murphy, Gianluca Bartolini Torres, Roksana Wygoda, Karol Garbaczewski, Giuseppe Forte, Giuseppe Consiglio, Yixuan Chen, Sébastien Perrier, Andreas Heise   +10 more
wiley   +2 more sources

Curation and Extraction of Drug-Related Entities from Reddit Platform. [PDF]

Proc (IEEE Int Conf Healthc Inform)
Wang Z, Xu Z, Wei Y, Chary M, Peng Y.
europepmc   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

Advancing bioinformatics with language models: components, applications, and perspectives. [PDF]

Brief Bioinform
Liu J, Yang M, Yu Y, Xu H, Wang T, Li K, Zhou X.   +6 more
europepmc   +1 more source