Results 241 to 250 of about 179,183 (295)

Optical Control of the Glucocorticoid Receptor Activity With a Photoswitchable Agonist

Angewandte Chemie, EarlyView.
A photoswitchable glucocorticoid receptor agonist enables optical control of receptor activity, achieving picomolar potency and partial agonism that preferentially maintains anti‐inflammatory signaling over canonical transcriptional activation. ABSTRACT Glucocorticoids (GCs) are widely prescribed anti‐inflammatory agents whose clinical utility is ...
Zoe Sessions, Chloé Van Leene, Dorien Clarisse, George Keen, Agnė Šveistytė, Dinahlee Saturnino Guarino, Robert H. Mach, Karolien De Bosscher, Dirk Trauner   +8 more
wiley   +1 more source

An intelligent assessment method for English translation teaching model based on improved BERT and attention mechanism. [PDF]

Sci Rep
Duan W.
europepmc   +1 more source

Conformation‐Selective Binding Domains of Intramolecular Chemically Induced Protein Dimerisation Systems

Angewandte Chemie, EarlyView.
Intramolecular chemically induced dimerisation transforms FK506‐ and cyclosporine A‐responsive protein pairs into high‐affinity pseudo‐allosteric switches. Holo‐selective binders isolated by mRNA display convert these switches into gain‐of‐signal biosensors and ultrasensitive ELISAs, enabling direct quantification of both immunosuppressants in ...
Zhenling Cui, Zhong Guo, Yi Jin Liew, Alessandro T. Caputo, Maria M. Fiorito, Cagla Ergun Ayva, Roxane Mutschler, Mayra Barrios Leguarca, Sophia Newton, Gia Nghi Lam, Robert Speight, Brett McWhinney, Yanulla Essie Georges, Carel Pretorius, Jacobus P.J. Ungerer, Kirill Alexandrov   +15 more
wiley   +1 more source

Dynamic Associations Between Public Risk Perception and Behavioral Responses on Weibo During the 2023 Beijing-Tianjin-Hebei Extreme Rainfall Event. [PDF]

Behav Sci (Basel)
Wang Y, Fan Y.
europepmc   +1 more source

Sequence-based artificial intelligence-guided inhibitory peptides to counteract AAV neutralizing antibodies in gene therapy. [PDF]

Mol Ther Adv
Xu B, Zhang X, Yu D, Wang P, Chi Y, Liu W, Xue F, Chen L, Li H, Wang W, Chen Y, Liu X, Fu R, Yang R, Shao W, Yu S, Pei X, Zhang L.   +17 more
europepmc   +1 more source

HELP-TCR: Harmonized Explainable Language Processing Toolkit for T Cell Antigen Receptor Repertoires. [PDF]

Comput Struct Biotechnol J
Kalesnik Y, Krawczyk D, Pietrzak M, Seweryn M.   +3 more
europepmc   +1 more source

Using Natural Language Processing to Examine State Child Maltreatment Policies and Associations With Outcomes: Multistate Cross-Sectional Study. [PDF]

JMIR Public Health Surveill
Luo Z, Epstein RA, Sambamoorthi N, Muhammad LN, Jordan N.   +4 more
europepmc   +1 more source

Deep learning-based natural language processing for critical care identification in pediatric emergency department. [PDF]

BMC Emerg Med
Kim JA, Cho S, Hwang M, Lee D, Jeon J, Lee R, Lee C, Kim J, Bae W.   +8 more
europepmc   +1 more source