Results 51 to 60 of about 179,183 (295)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
CoRR, 2021 Language is an outcome of our complex and dynamic human-interactions and the technique of natural language processing (NLP) is hence built on human linguistic activities. Bidirectional Encoder Representations from Transformers (BERT) has recently gained its popularity by establishing the state-of-the-art scores in several NLP benchmarks.
Katsuma Inoue +3 more
openaire +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Journal of Intelligent ConstructionBuilding information modeling (BIM) and robotic technologies are revolutionizing the construction industry. The integration of BIM and robotics has the potential to enhance workforce skills, improve safety, and optimize construction processes.
Obiora Odugu +4 more
doaj +1 more source
Jurnal Riset Informatika, 2023 Tax is an obligation that arises due to the existence of laws, creating a duty for citizens to contribute a certain portion of their income to the state. The Tax Court serves as a judicial authority for taxpayers seeking justice in tax disputes, handling
Ade Putera Kemala, Hafizh Ash Shiddiqi
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Cancer & MetabolismEstrogen receptor (ER)-positive breast cancer (BC) is a prevalent and fatal cancer among women, and there is a need to identify molecules involved in the disease pathophysiology which could also serve as biomarkers for early detection.
Yamama Abu Mohsen +15 more
doaj +1 more source
Automatic construction accident report analysis using large language models (LLMs)
Journal of Intelligent ConstructionConstruction site safety is a paramount concern, given the high rate of accidents and fatalities in the sector. This study introduces a novel approach to analyzing construction accident reports by employing advanced large language models (LLMs ...
Ehsan Ahmadi, Shashank Muley, Chao Wang
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source