Results 61 to 70 of about 8,388 (214)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Automatic construction accident report analysis using large language models (LLMs)

Journal of Intelligent Construction
Construction site safety is a paramount concern, given the high rate of accidents and fatalities in the sector. This study introduces a novel approach to analyzing construction accident reports by employing advanced large language models (LLMs ...
Ehsan Ahmadi, Shashank Muley, Chao Wang
doaj   +1 more source

Abstractive and Extractive Approaches for Summarizing Multi-document Travel Reviews

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi), 2023
Travel reviews offer insights into users' experiences at places they have visited, including hotels, restaurants, and tourist attractions. Reviews are a type of multidocument, where one place has several reviews from different users.
Narandha Arya Ranggianto, Diana Purwitasari, Chastine Fatichah, Rizka Wakhidatus Sholikah   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Proteomic and lipidomic analysis of low-density lipoprotein identifies potential biomarkers of early estrogen receptor-positive breast cancer

Cancer & Metabolism
Estrogen receptor (ER)-positive breast cancer (BC) is a prevalent and fatal cancer among women, and there is a need to identify molecules involved in the disease pathophysiology which could also serve as biomarkers for early detection.
Yamama Abu Mohsen, Rachel Twitto-Greenberg, Anna Cohen, Gil S Leichner, Lidor Mahler, Hofit Cohen, Yehuda Kamari, Aviv Shaish, Ayelet Harari, Alicia Leikin-Frenkel, Efrat Glick Saar, Tamar Geiger, Sergey Malitsky, Maxim Itkin, Dror Harats, Rom Keshet   +15 more
doaj   +1 more source

BIM-driven robotics in construction: A systematic review of integration methods, applications, and future directions

Journal of Intelligent Construction
Building information modeling (BIM) and robotic technologies are revolutionizing the construction industry. The integration of BIM and robotics has the potential to enhance workforce skills, improve safety, and optimize construction processes.
Obiora Odugu, Fatemeh Ghafari, Ehsan Shourangiz, Muhammad Tahir Khan, Chao Wang   +4 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Transient Chaos in BERT

CoRR, 2021
Language is an outcome of our complex and dynamic human-interactions and the technique of natural language processing (NLP) is hence built on human linguistic activities. Bidirectional Encoder Representations from Transformers (BERT) has recently gained its popularity by establishing the state-of-the-art scores in several NLP benchmarks.
Katsuma Inoue, Soh Ohara, Yasuo Kuniyoshi, Kohei Nakajima   +3 more
openaire   +2 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source