Results 181 to 190 of about 342,725 (270)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Eating disorders risk assessment and body esteem among elite polish contact karate athletes. [PDF]

Front Nutr
Dobkowska-Szefer D, Staśkiewicz-Bartecka W, Kiciak A, Kardas M.   +3 more
europepmc   +1 more source

Being Strange While Being No One [PDF]

Frontiers in Psychology, 2018
openaire   +4 more sources

Electrochemiluminescence Drives Photodynamic Therapy In Vivo

Advanced Science, EarlyView.
Electrochemiluminescence (ECL)‐driven photodynamic therapy (PDT) for in vivo cancer treatment is reported for the first time. The flexible ECL patch exhibits stable and intense luminance under alternating current voltage, enabling efficient photosensitization to generate reactive oxygen species that damage cancer cells, thus leading to significant ...
Jia‐Bao Lin, Ling‐Ling Xu, Yong Liu, Hang Gao, Hong‐Yuan Chen, Jing‐Juan Xu   +5 more
wiley   +1 more source

Bioelectrochemical Systems: Prioritizing Energy Density, Long-Term Stability, and Validation. [PDF]

ACS Energy Lett
Faria LCI, Nascimento SQ, Lima FCDA, Sedenho GC, Bertaglia T, Iost RM, de Souza JCP, Lanceros-Méndez S, Minteer SD, Cosnier S, Furst AL, Crespilho FN.   +11 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Research progress of base editing and prime editing tools based on the CRISPR/Cas system. [PDF]

Mol Ther Nucleic Acids
Gao H, Gao S, Kan G, Valentovich LN, An Y.   +4 more
europepmc   +1 more source

Transient Antiskyrmion‐Mediated Topological Transitions in Isotropic Magnets

Advanced Science, EarlyView.
A transient antiskyrmion‐mediated pathway that drives repeated stripe‐to‐skyrmion transitions is revealed, producing a net increase in topological charge in isotropic Dzyaloshinskii–Moriya interaction films. Experiments and simulations identify the antiskyrmion as a metastable excitation, enabling stochastic bitstream generation for probabilistic ...
Bingqian Dai, Tianyi Wang, Albert Lee, Shijie Xu, Zhongjian Bian, Xinyue Zhu, Puyang Huang, Aadi Chaturvedi, Yaochen Li, Yang Cheng, Qingyuan Shu, Haoran He, Hanshen Huang, Lixuan Tai, Kin Wong, Jinbo Yang, Anjan Soumyanarayanan, Zhaochu Luo, Kang L. Wang   +18 more
wiley   +1 more source

Corrigendum to "Environmental benefits of blue ecosystem services and residents' willingness to pay in Khulna city, Bangladesh" [Heliyon Volume 8, Issue 5, May 2022, Article e09535]. [PDF]

Heliyon
Haque MN, Saroar M, Fattah MA, Morshed SR.   +3 more
europepmc   +1 more source