Results 111 to 120 of about 220,874 (298)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Time Average Replicator and Best Reply Dynamics [PDF]

Using an explicit representation in terms of the logit map we show, in a unilateral framework, that the time average of the replicator dynamics is a perturbed solution of the best reply dynamics.replicator dynamics; best reply dynamics; logit map ...
Yannick Viossat, Josef Hofbauer, Sylvain Sorin   +2 more
core  

Best piecewise monotone uniform approximation

, 1990
The problem considered is that of finding a best uniform approximation to a real function f ∈ C[a, b] from the class of piecewise monotone functions.
Ubhaya, Vasant A, Xu, Yuesheng, Weinstein, S.E   +2 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Rational approximation of discrete data with asymptomatic behaviour

This thesis is concerned with the least-squares approximation of discrete data that appear to exhibit asymptotic behaviour. In particular, we consider using rational functions as they are able to display a number of types of asymptotic behaviour.
Cooper, Philip
core  

The Best -Approximation Weighted-Residuals Method for Finite Element Approximations

, 2009
In this article it is presented a Petrov-Galerkin method which gives a least-squares solution, useful for that problems for which the standard Galerkin method wildly oscillates and does not give an optimal approximation.
MARCUZZI, FABIO, MORANDI CECCHI M
core  

A result on best approximation in $p$-normed spaces [PDF]

, 2001
summary:We study best approximation in $p$-normed spaces via a general common fixed point principle. Our results unify and extend some known results of Carbone [ca:pt], Dotson [do:bs], Jungck and Sessa [ju:at], Singh [si:at] and many of ...
Latif, Abdul
core  

On a dual characterisation in best approximation problem

Journal of Numerical Analysis and Approximation Theory, 2008
We establish a dual characterization of solutions of Ky Fan best approximation problem and as consequence we obtain an existence criterium under conditions formulated for the weak topology.
Teodor Precupanu
doaj   +2 more sources

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source