Results 91 to 100 of about 3,815,474 (195)

Explicit algebraic solution of Zolotarev's First Problem for low-degree polynomials

Journal of Numerical Analysis and Approximation Theory, 2019
E.I. Zolotarev's classical so-called First Problem (ZFP), which was posed to him by P.L. Chebyshev, is to determine, for a given \(n\in{\mathbb N}\backslash\{1\}\) and for a given \(s\in{\mathbb R}\backslash\{0\}\), the monic polynomial solution \(Z ...
Heinz Joachim Rack, Robert Vajda
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Weighted Extremal Domains and Best Rational Approximation

, 2012
44 pages, 5 figuresLet f be holomorphically continuable over the complex plane except for finitely many branch points contained in the unit disk. We prove that best rational approximants to f of degree n, in the L^2-sense on the unit circle, have poles ...
Stahl, Herbert, Baratchart, Laurent, Laurent Baratchart, Yattselev, Maxim, Herbert Stahl, Maxim Yattselev   +5 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Best approximation over the whole complex plane [PDF]

, 1982
Best rational approximation over the whole complex plane is investigated. While existence is elementary, there is not always uniqueness—every constant may be the best constant approximation to f(z) = z.
Lubinsky, D.S, Shisha, O
core   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

ON WIDTHS OF SOME CLASSES OF ANALYTIC FUNCTIONS IN A CIRCLE

Ural Mathematical Journal
We calculate exact values of some $n$-widths of the class \(W_{q}^{(r)}(\Phi),\) \(r\in\mathbb{Z}_{+},\) in the Banach spaces \(\mathscr{L}_{q,\gamma}\) and \(B_{q,\gamma},\) \(1\leq q\leq\infty,\) with a weight \(\gamma\).
Mirgand Sh. Shabozov, Muqim S. Saidusainov   +1 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source