Results 121 to 130 of about 88,700 (323)
"Prediction in Multivariate Mixed Linear Models" [PDF]
The multivariate mixed linear model or multivariate components of variance model with equal replications is considered.The paper addresses the problem of predicting the sum of the regression mean and the random e ects.When the feasible best linear ...
M. S. Srivastava, Tatsuka Kubokawa
core
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source
Out of Sample Estimation for Small Areas using Area Level Data
, 2005 A Fay-Herriot type model with independent area effects is often assumed when small area estimates based on area level data are required. However, under this approach out of sample areas are limited to synthetic estimates.
Chambers, Ray, Saei, Ayoub
core
Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins
Advanced Science, EarlyView.Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang +3 more
wiley +1 more source
Advanced Science, EarlyView.This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue +17 more
wiley +1 more source
Best Widely Linear Unbiased Estimator for Real Valued Parameter Vectors [PDF]
, 2016 Oliver Lang, Mario Huemer
openalex +1 more source
Experimental Joint Estimation of Phase and Phase Diffusion Via Deterministic Bell Measurements
Advanced Science, EarlyView.This work employs Bell measurement, a form of entangling measurement, to estimate both the phase and its fluctuations in an optical interferometer. By incorporating a novel quantum effect at the measurement stage, the proposed method achieves the ultimate precision limit and demonstrates the significant potential of entangling measurements in multi ...
Ben Wang +4 more
wiley +1 more source
Advanced Science, EarlyView.This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao +14 more
wiley +1 more source
Advanced Science, EarlyView.Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin +18 more
wiley +1 more source