Results 131 to 140 of about 6,570,426 (256)

Expanded characterization of the valproic acid zebrafish larval model of autism spectrum disorder: Insights into dysregulation in the gut

Animal Models and Experimental Medicine, EarlyView.
Meticulous calculation of zebrafish‐equivalent therapeutic valproic acid (VPA) dosage maximized the translational value of the data. Hyposerotonergic tone underpinned an anxiety‐like outcome as a core symptom of autism spectrum disorder (ASD). Compartment‐specific dopaminergic and serotonergic dysregulation in the brain versus gut provided mechanistic ...
Lesha Pretorius, Johanna Adriana Coetzee, Alexio Pedro dos Santos, Carine Smith   +3 more
wiley   +1 more source

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, EarlyView.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +1 more source

On equality and proportionality of ordinary least squares, weighted least squares and best linear unbiased estimators in the general linear model

Equality and proportionality of the ordinary least-squares estimator (OLSE), the weighted least-squares estimator (WLSE), and the best linear unbiased estimator (BLUE) for X[beta] in the general linear (Gauss-Markov) model are investigated through the ...
Tian, Yongge, Wiens, Douglas P.
core  

Positivity of the best unbiased L-estimator of the scale parameter with complete or selected order statistics from location-scale distribution

The positivity of the best linear unbiased estimator of the scale parameter of a location-scale family of distributions in terms of complete or selected set of order statistics has only been conjectured in the literature based solely on empirical ...
Sarkar, Sanat K., Wang, Wenjin, Bai, Zhidong   +2 more
core  

Residual Strength Prediction of Chemically Reactive Two‐Phase Nanofluid Flow in a Bingham–Papanastasiou Rheological Theory Using a Morlet‐Based Wavelet Neural Network Approach

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The behavior of nanofluid flow involving a zero‐mass flux condition has received considerable interest because of a realistic scenario. In reality, this condition confines the optimistic accumulation or disappearance of nanoparticles past a sheet, constructing a more physically realistic demonstration through several applications, such as heat
Umair Khan, Hamza Rauf, Aurang Zaib, J. K. Madhukesh   +3 more
wiley   +1 more source

New insights into best linear unbiased estimation and the optimality of least-squares

New results in matrix algebra applied to the fundamental bordered matrix of linear estimation theory pave the way towards obtaining additional and informative closed-form expressions for the best linear unbiased estimator (BLUE).
Faliva, Mario, Zoia, Maria Grazia
core  

Multivariate Analysis of Hematological Stress Biomarkers and Welfare Domains in Organic and Intensive Pig Farming in Italy: A Pilot Study

Animal Research and One Health, EarlyView.
Intensive or organic farming systems may expose pigs to management or environmental challenges. Our preliminary results concluded that organic farming might enhance adaptive immune function, showing that improvements in welfare can translate into measurable immunological benefits, based on the correlation between welfare assessment and physiological ...
Dorotea Ippolito, Talal Hassan, Antonio Marco Maisano, Stefania Bergagna, Cecilia Guasco, Barbara Miniscalco, Martina Tarantola, Elena Colombino, Claudio Caruso, Ahsan Muhammad, Silvia Mioletti, Laura Tomassone, Massimiliano Tursi, Cristina Vercelli, Giovanni Loris Alborali, Maria Teresa Capucchio   +15 more
wiley   +1 more source

A workflow for 3D printing highly accurate, customized human skull models for anatomical education and clinical practice

Anatomical Sciences Education, EarlyView.
Our custom workflow creates anatomically accurate and diverse 3D skull models. Precise sex‐specific anatomical detail is ensured by CT‐based segmentation. Our models capture anatomical variations and pathologies. Our cost‐effective 3D printing workflow enhances model durability and fidelity.
Marina Moser, Michel Beyer, Magdalena Müller‐Gerbl, Sandra Blache, Florian M. Thieringer, Szilvia Mezey   +5 more
wiley   +1 more source

Driving continuous improvement of sustainability certification for industrial biobased systems through comprehensive sustainability requirements

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Existing monitoring frameworks for sustainability certification schemes and labels (CSLs) have largely prioritised environmental aspects, while the social and economic pillars of sustainability remain comparatively underdeveloped. Also, dedicated circularity requirements tailored to biobased systems are still largely lacking, despite being ...
Iris Vural Gursel, Heleen Ballemans, Heike Axmann, Lesly Garcia‐Chavez, Marta Rodriguez‐Illera, Laura Väyrynen   +5 more
wiley   +1 more source

Best affine unbiased representations of the fully restricted general Gauss-Markov model

This article completes and simplifies earlier results on the derivation of best linear, or affine, unbiased estimates in the general Gauss-Markov model with a singular dispersion matrix and additional restrictions under very general conditions.
Haupt, Harry, Oberhofer, Walter
core