Results 101 to 110 of about 194,005 (326)

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

On simultaneous best linear unbiased prediction of future order statistics and associated properties [PDF]

Journal of Multivariate Analysis, 2021
N. Balakrishnan, Ritwik Bhattacharya
semanticscholar   +1 more source

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

Advanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park, Ji‐Hyun Kim, Hunki Lee, Chungwon Park, Sidong Chen, Luke Bates, Jaeyoung Sung, Hyokeun Park   +7 more
wiley   +1 more source

Enhancing Genomic Prediction Accuracy in Beef Cattle Using WMGBLUP and SNP Pre-Selection

Agriculture
Genomic selection (GS) plays a crucial role in livestock breeding. However, its implementation in Chinese beef cattle breeding is constrained by a limited reference population and incomplete data records.
Huqiong Zhao, Xueyuan Xie, Haoran Ma, Peinuo Zhou, Boran Xu, Yuanqing Zhang, Lingyang Xu, Huijiang Gao, Junya Li, Zezhao Wang, Xiaoyan Niu   +10 more
doaj   +1 more source

About predictions in spatial autoregressive models: Optimal and almost optimal strategies [PDF]

We address the problem of prediction in the classical spatial autoregressive lag model for areal data. In contrast with the spatial econometrics literature, the geostatistical literature has devoted much attention to prediction using the Best Linear ...
Goulard, Michel, Laurent, Thibault, Thomas-Agnan, Christine   +2 more
core   +1 more source

Cheaper and Better: Selecting Good Workers for Crowdsourcing

, 2015
Crowdsourcing provides a popular paradigm for data collection at scale. We study the problem of selecting subsets of workers from a given worker pool to maximize the accuracy under a budget constraint.
Li, Hongwei, Liu, Qiang
core   +2 more sources

Genetic Parameters and Selection in Full-Sib Families of Tall Fescue Using Best Linear Unbiased Prediction (BLUP) Analysis of Animal Breeding and Genetic [PDF]

, 2021
Fatemeh Pirnajmedin, Mohammad Mahdi Majidi, Mohammad Hadi Taleb, Davoud Rostami   +3 more
openalex   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Integrating Gene Expression Data into Single-Step Method (ssBLUP) Improves Genomic Prediction Accuracy for Complex Traits of Duroc × Erhualian F₂ Pig Population

Current Issues in Molecular Biology
The development of multi-omics has increased the likelihood of further improving genomic prediction (GP) of complex traits. Gene expression data can directly reflect the genotype effect, and thus, they are widely used for GP.
Fangjun Xu, Zhaoxuan Che, Jiakun Qiao, Pingping Han, Na Miao, Xiangyu Dai, Yuhua Fu, Xinyun Li, Mengjin Zhu   +8 more
doaj   +1 more source

Biased-estimations of the Variance and Skewness

, 1998
Nonlinear combinations of direct observables are often used to estimate quantities of theoretical interest. Without sufficient caution, this could lead to biased estimations.
Baugh C. M., Baugh C. M., Bernardeau F., Bernardeau F., Colombi S., Dalton G. B., Efstathiou G., Gaztanaga E., Gaztanaga E., Kaiser N., Kerscher M.   +10 more
core   +1 more source