Results 241 to 250 of about 179,787 (326)

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

A novel, major, and validated QTL for grain zinc concentration independent of yield traits in tetraploid wheat. [PDF]

Plant Genome
Zeng Z, Ma J, Chen B, Tang H, Xian X, Huo Y, Xu Y, Tang X, Gao X, Chen G.   +9 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Impact of Selection Signature on Genomic Prediction and Heritability Estimation in Livestock. [PDF]

Animals (Basel)
Zhang H, Pang Z, Wang W, Qiao L, Liu W.
europepmc   +1 more source

A Real‐World Study on Unstable Parkinson's Disease: Levodopa Dosage Management and the Role of Nonmotor Symptoms

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a neurodegenerative disorder associated with motor and nonmotor symptoms. Objectives This study assesses levodopa dose management, the therapeutic goals of clinicians, the factors that influence clinicians' choice of therapy, and the role of nonmotor symptoms using real‐world evidence from Germany, Italy,
Fabrizio Stocchi, Jaime Kulisevsky, Wolfgang H. Jost   +2 more
wiley   +1 more source

Decision‐Making in M&A Under Market Mispricing: The Role of Deep Learning Models

Managerial and Decision Economics, EarlyView.
ABSTRACT In the ever‐evolving landscape of financial markets, mergers and acquisitions (M&A) play a pivotal role in shaping the corporate ecosystem. However, the presence of market mispricing, driven by various factors such as information asymmetry, behavioral biases, and external shocks, has been a persistent challenge for investors and corporations ...
Yuxuan Tang
wiley   +1 more source

Metabolomic-genomic prediction realizes small increases in accuracy of estimated breeding values for daily gain in pigs. [PDF]

Genet Sel Evol
Guo X, Sarup P, Bay Nord A, Henryon M, Ostersen T, Christensen OF.   +5 more
europepmc   +1 more source

Trajectories of Pontine Volume in Patients with Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Objectives To investigate trajectories of regional brain volume changes in multiple system atrophy (MSA) and their potential utility as surrogate markers of disease progression in the cerebellar subtype (MSA‐C). Background Reliable biomarkers for tracking disease progression in MSA are urgently needed.
Kazuya Kawabata, Florian Krismer, Mizuki Ito, Kazuhiro Hara, Epifanio Bagarinao, Vincent Beliveau, Patrice Péran, Germain Arribarat, Anne Pavy‐Le Traon, Wassilios G. Meissner, Alexandra Foubert‐Samier, Margherita Fabbri, Mark Forrest Gordon, Aya Ogura, Masahisa Katsuno, Olivier Rascol, Christoph Scherfler, Klaus Seppi, Hirohisa Watanabe, Werner Poewe   +19 more
wiley   +1 more source

Estimation of ryegrass (<i>Lolium</i>) dry matter yield using genomic prediction considering genotype by environment interaction across south-eastern Australia. [PDF]

Front Plant Sci
Zhu J, Giri K, Lin Z, Cogan NO, Jacobs JL, Smith KF.   +5 more
europepmc   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

Movement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles, Dilan Athauda, Thomas R. Barber, Roger A. Barker, David T. Dexter, Susan Duty, Romy Ellis‐Doyle, Sonia Gandhi, Joel Handley, Edwin Jabbari, Keith Martin, Kevin McFarthing, Georgia Mills, Heather Mortiboys, Stephen Mullin, Rebecca Petty, Esther Sammler, Paula Scurfield, Simon R.W. Stott, George K. Tofaris, Li Wei, Caroline H. Williams‐Gray, Alan Wong, Marie‐Louise Zeissler, Richard K. Wyse, Camille B. Carroll, Thomas Foltynie, Oliver Bandmann, Anthony H.V. Schapira, on behalf of the EJS ACT‐PD Consortium   +29 more
wiley   +1 more source