Results 151 to 160 of about 63,623 (238)

Tailoring Multifunctional Carbon Dots via Precursor Stoichiometry: Switching Between Solid‐State Fluorescence and Broadband Absorption Through Aggregation Control

Advanced Science, EarlyView.
Precursor stoichiometry programs the surface chemistry of carbon dots, directing their self‐assembly into distinct aggregation modes. Aldehyde‐enriched surfaces form ordered, hydrogen‐bonded assemblies that enable bright red solid‐state fluorescence, whereas amine‐rich surfaces promote compact π–π stacked aggregates with broadband visible‐light ...
Gaixia Yang, Hao Sun, Defa Hou, Fulin Yang, Yuan Zou, Bei Zhou, Lanxiang Liu, Xu Lin, Guanben Du   +8 more
wiley   +1 more source

Direct-to-Biology Enabled Molecular Glue Discovery. [PDF]

J Am Chem Soc
Hu M, Ochoada J, Actis M, McGowan K, Jarusiewicz JA, Yoshimura S, McGrath L, Neelakantan U, Aggarwal A, Mayasundari A, Young SM, Zhang M, Yang L, Li Y, Mercer S, Babu MM, Fischer M, Young BM, Yang JJ, Nishiguchi G, Shelat AA, Blair DJ.   +21 more
europepmc   +1 more source

Asymmetrically Fluorinated Phenyl 4‐biphenylcarboxylate Motifs as a Design Principle for Enantiotropic Ferroelectric Liquid Crystals

Advanced Science, EarlyView.
The effect of the structural arrangement of DIO and its analogs on ferroelectric phases is explored. Consequently, it is found that an asymmetrically fluorinated phenyl 4‐biphenylcaroboxylate skeleton is one of the favorable structural motifs for the emergence of enantiotropic ferroelectric liquid crystal phases.
Hiroyuki Matsukizono, Koichiro Hayashi, Keiko Kojima, Yasushi Okumura, Hirotsugu Kikuchi   +4 more
wiley   +1 more source

Preference for symmetry, balance, or proximity in picture aesthetics depends on the method of evaluation. [PDF]

Iperception
Hübner R.
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

CytoSignal detects locations and dynamics of ligand-receptor signaling at cellular resolution from spatial transcriptomic data. [PDF]

Nat Genet
Liu J, Manabe H, Qian W, Orikasa S, Ghaemmaghami J, Wang Y, Gu Y, Chu AKY, Gadhvi G, Song Y, McClinden P, Lama VN, Ono N, Welch JD.   +13 more
europepmc   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Intraspecific interactions in spring-staging geese reflect mate guarding and proximity to nesting dates. [PDF]

Sci Rep
Polakowski M, Jankowiak Ł, Fox AD.
europepmc   +1 more source

stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics

Advanced Science, EarlyView.
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang, Yan Wang, Luonan Chen, Chunman Zuo   +3 more
wiley   +1 more source

Quantitative FRET FLIM imaging reveals multiple interactions between proteins of the ESYT, ORP, and VAP families at the endoplasmic reticulum membrane. [PDF]

J Biol Chem
Zamiati D, Abdesselem M, Nüsse O, Erard M.   +3 more
europepmc   +1 more source