Results 51 to 60 of about 4,213,432 (261)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Cyclic contractions and best proximity pair theorems
, 2010 This paper has been ...
Kosuru, G. Sankara Raju, Veeramani, P.
openaire +2 more sources
Best proximity pair and fixed point results for noncyclic mappings in convex metric spaces
, 2016 In this article, we formulate a best proximity pair theorem for noncyclic relatively nonexpansive mappings in convex metrc spaces by using a geometric notion of semi-normal structure.
Moosa Gabeleh, Naseer Shahzad
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FilomatIn the setup of metric spaces, many recent studies established a significant variety of control type mappings and illustrated some fixed point results. To represent various contractivity conditions, Khojasteh et al. have established the idea of a simulation function and came up with certain conclusions about the fixed point. For two nonlinear operators
P PaunovicMarija +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Cyclic (noncyclic) phi-condensing operator and its application to a system of differential equations
Nonlinear Analysis, 2019 We establish a best proximity pair theorem for noncyclic φ-condensing operators in strictly convex Banach spaces by using a measure of noncompactness. We also obtain a counterpart result for cyclic φ-condensing operators in Banach spaces to guarantee the
Moosa Moosa Gabeleh +2 more
doaj +3 more sources