Results 51 to 60 of about 4,446,313 (251)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Best proximity pair and fixed point results for noncyclic mappings in convex metric spaces

, 2016
In this article, we formulate a best proximity pair theorem for noncyclic relatively nonexpansive mappings in convex metrc spaces by using a geometric notion of semi-normal structure.
Moosa Gabeleh, Naseer Shahzad
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Common Best Proximity Point Theorem for Ï•-dominated Pair

European Journal of Pure and Applied Mathematics, 2018
In the present research, an interesting common best proximity point theorem for pairs of non-self-mappings is presented. It satises a weakly contraction-like condition, thereby producing common optimal approximate solutions of certain simultaneous xed point equations.
Iranmanesh, Mahdi, Sanatee, Ali Ganjbakhsh   +1 more
openaire   +2 more sources

Non-convex proximal pair and relatively nonexpansive maps with respect to orbits

Journal of Inequalities and Applications, 2021
Every non-convex pair ( C , D ) $(C, D)$ may not have proximal normal structure even in a Hilbert space. In this article, we use cyclic relatively nonexpansive maps with respect to orbits to show the presence of best proximity points in C ∪ D $C\cup D$ ,
Laishram Shanjit, Yumnam Rohen
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Cyclic (noncyclic) phi-condensing operator and its application to a system of differential equations

Nonlinear Analysis, 2019
We establish a best proximity pair theorem for noncyclic φ-condensing operators in strictly convex Banach spaces by using a measure of noncompactness. We also obtain a counterpart result for cyclic φ-condensing operators in Banach spaces to guarantee the
Moosa Moosa Gabeleh, Philemon Moshokoa, Calogero Vetro   +2 more
doaj   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Best proximity version of Krasnoselskii's fixed point theorem

, 2020
We prove a best proximity point version of Krasnoselskii’s fixed point theorem. As a consequence we obtain the existence of best proximity points of relatively u-continuous maps for a pair of compact convex ...
Veeramani P., Kar S.
core