Results 221 to 230 of about 4,206,969 (256)
DNA-Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity. [PDF]
SmallElnaggar M, Heuer-Jungemann A.
europepmc +1 more source
Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations
Advanced Science, EarlyView.Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford +3 more
wiley +1 more source
Inferring signed social networks from contact patterns. [PDF]
J Phys ComplexFerenczi D, Young JG, Peel L.
europepmc +1 more source
Advanced Science, EarlyView.The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt +16 more
wiley +1 more source
Optical Coastal GNSS-Denied Navigation for Reduction in AUV Underwater Navigation Error. [PDF]
Sensors (Basel)Praczyk T, Zalewski J.
europepmc +1 more source
Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning
Advanced Science, EarlyView.SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley +1 more source
Topological mixing and irreversibility in animal chromosome evolution. [PDF]
Sci AdvSchultz DT +4 more
europepmc +1 more source
Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography
Advanced Science, EarlyView.Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian +12 more
wiley +1 more source
A network-based map of the chemical exposome connects molecular interactions to public health. [PDF]
Nat CommunLombardo SD +3 more
europepmc +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source