Results 41 to 50 of about 65,457 (238)
Mathematics, 2022 (1) Background: In silico approaches to rational drug design are among the fastest evolving ones. Depending on the available structural information for the biomacromolecule and the small molecule, the in silico methods are classified as ligand- and ...
Dessislava Jereva +9 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Existence and Convergence of Best Proximity Points for Semi Cyclic Contraction Pairs
International Journal of Analysis and Applications, 2014 In this article, we introduce the notion of a semi cyclic ϕ-contraction pair of mappings, which contains semi cyclic contraction pairs as a subclass.
Balwant Singh Thakur, Ajay Sharma
doaj +2 more sources
When Should Recommenders Account for Low QoS?
IEEE Access, 2023 Content recommendation systems, also known as recommenders, are pervasive and have significant impact on user demands over the Internet. Platforms such as YouTube and Netflix constantly seek to improve their recommendation systems, to provide better ...
Mateus Schulz Nogueira +5 more
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FilomatIn the setup of metric spaces, many recent studies established a significant variety of control type mappings and illustrated some fixed point results. To represent various contractivity conditions, Khojasteh et al. have established the idea of a simulation function and came up with certain conclusions about the fixed point. For two nonlinear operators
P PaunovicMarija +2 more
openaire +1 more source
Cyclic contractions and best proximity pair theorems
, 2010 This paper has been ...
Kosuru, G. Sankara Raju, Veeramani, P.
openaire +2 more sources
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
A Common Best Proximity Point Theorem for Ï•-dominated Pair
European Journal of Pure and Applied Mathematics, 2018 In the present research, an interesting common best proximity point theorem for pairs of non-self-mappings is presented. It satises a weakly contraction-like condition, thereby producing common optimal approximate solutions of certain simultaneous xed point equations.
Iranmanesh, Mahdi +1 more
openaire +2 more sources