Results 41 to 50 of about 4,206,969 (256)
Machines, 2023 The need of compact machines increased in recent years due to increases in raw materials’ price. Hence, many studies are currently being conducted on high-speed challenges to propose an optimal design methodology.
Taha El Hajji +5 more
doaj +1 more source
Aircraft Wake Vortex Decay in Ground Proximity : Physical Mechanisms and Artificial Enhancement [PDF]
, 2012 Aircraft wake vortex evolution in ground proximity is investigated numerically with large eddy simulations (LES). The simulations are performed with different modifications of the ground surface in order to trigger rapid vortex decay or to simulate the ...
Anton Stephan +5 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Mathematics, 2022 In this paper, a multivalued self-mapping is defined on the union of a finite number of subsets p≥2 of a metric space which is, in general, of a mixed cyclic and acyclic nature in the sense that it can perform some iterations within each of the subsets ...
Manuel De la Sen, Asier Ibeas
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Modular best proximity and equilibrium pairs in free generalized games
, 2017 In this paper, we prove a fixed point theorem for ?-acyclic factorizable multifunction. Some existence theorems of general best proximity pairs and equilibrium pairs are presented in modular function spaces.
Nasrin Karamikabir, Farajollah Yaghoobi
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Mathematics, 2022 (1) Background: In silico approaches to rational drug design are among the fastest evolving ones. Depending on the available structural information for the biomacromolecule and the small molecule, the in silico methods are classified as ligand- and ...
Dessislava Jereva +9 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source