Results 111 to 120 of about 7,346,118 (311)

Pengaruh Penambahan Polivinil Alkohol pada Biomassa Tongkol Jagung-Bulu Ayam sebagai Adsorben Campuran Ion Logam Timbal (Pb2+) dan Ion Logam Krom Total

Jurnal Kimia Sains dan Aplikasi, 2015
Penelitian tentang pengaruh penambahan polivinil alkohol (PVA) pada biomassa tongkol jagung-bulu ayam untuk adsorben campuran ion timbal (Pb2+) dan ion krom total telah dilakukan.
Aulannisa Elqudsy, Rum Hastuti, Didik Setiyo Widodo   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

BEaTmap: Simplified Rigorous BET Analysis of Isothermal Adsorption Data

Journal of Open Research Software
BEaTmap is an open-source software designed to improve the analysis of isothermal adsorption data. The specific surface area of a porous material is commonly obtained through applying the classic BET theory to the adsorption of inert gases and vapors in ...
Ellsworth Bell, David Morris, Mohammad Amin Sadeghi, Jeff Gostick   +3 more
doaj   +1 more source

Entre « jouer avec » l’argent et « parier pour » l’argent : une analyse sociologique du double statut de l’argent du jeu en Chine

Sciences du Jeu, 2015
Without prejudging the specific function of money in games, the term “gambling” (or literally translated from French, “game of money”) seems to be rather confusing for the scientific understanding of the activities this term actually refers to: We ...
Shen Hu
doaj   +1 more source

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression

Journal of Medicinal Chemistry, 2017
The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic “readers” and play a key role in the regulation of gene transcription. BET proteins are considered to be attractive
Bing Zhou, Jiantao Hu, Fuming Xu, Zhuo Chen, Long-Chuan Bai, E. Fernández-Salas, Mei Lin, Liu Liu, Chao-Yie Yang, Yu-Jun Zhao, D. McEachern, S. Przybranowski, Bo Wen, Du-Xin Sun, Shaomeng Wang   +14 more
semanticscholar   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

Epigenetics, 2018
The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET ...
Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon, Marina Lizio, Masatoshi Wakamori, Takayoshi Matsuda, Takuhiro Ito, Prashanti Jeyamohan, Yuko Sato, Kensaku Sakamoto, Shigeyuki Yokoyama, Hiroshi Kimura, Aki Minoda, Takashi Umehara   +13 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source