Results 91 to 100 of about 7,346,118 (311)
Stability and function of regulatory T cells expressing the transcription factor T-bet
Nature, 2017 Adaptive immune responses are tailored to different types of pathogens through differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T helper 1 (TH1), TH2, and TH17) defined by expression of the key transcription ...
Andrew G Levine +13 more
semanticscholar +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
One Health, 2018 Thus far, no human MERS-CoV infections have been reported from Israel. Evidence for the circulation of MERS-CoV in dromedaries has been reported from almost all the countries of the Middle East, except Israel.
Dan David +10 more
doaj +1 more source
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains
Molecules and Cells, 2019 Summary Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases.
Jean-Philippe Lambert +19 more
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
ACS Chemical Biology, 2015 The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1.
Michael Zengerle +2 more
semanticscholar +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Lifetime Prediction of Polymers: To Bet, or Not to Bet—Is This the Question? [PDF]
Materials, 2018 Polymers are a great and very important category of organic compounds that have changed our lifestyle. In the last eighty years, we have used them for the most varied applications, and from the first structural ones we began to investigate their durability, which can be fatal in the successful completion of the application for which the material was ...
openaire +3 more sources
Artificial diet for two flat-headed borers, Capnodis spp. (Coleoptera: Buprestidae)
European Journal of Entomology, 2009 The main objective was to develop an artificial diet for two flat-headed borers, Capnodis tenebrionis L. and C. carbonaria Klug. (Coleoptera: Buprestidae), which are severe pests of stonefruit plantations in the Mediterranean basin.
Galina GINDIN +4 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source