Results 81 to 90 of about 7,346,118 (311)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

BET inhibitor suppresses melanoma progression via the noncanonical NF-κB/SPP1 pathway

Theranostics, 2020
Background: Bromodomain and extra-terminal domain (BET) inhibitors have shown profound efficacy against hematologic malignancies and solid tumors in preclinical studies. However, the underlying molecular mechanism in melanoma is not well understood. Here
Guang-Tong Deng, Fu-Rong Zeng, Juan Su, Shuang Zhao, Rui Hu, Wu Zhu, Shuo Hu, Xiang Chen, Ming-Zhu Yin   +8 more
semanticscholar   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Study of Porosity and Surface Groups of Activated Carbons Produced from Alternative and Renewable Biomass: Buriti Petiole

Orbital: The Electronic Journal of Chemistry, 2017
This study reports the production of activated carbon (AC) from chemical activation with sodium hydroxide in pyrolysis temperature of 500 to 600 °C using alternative and renewable material, Buriti petiole.
Cristiane Freitas de Almeida, Robson Carlos de Andrade, Giulyane Felix de Oliveira, Patricia Hatsue Suegama, Eduardo José de Arruda, José Augusto Texeira, Claudio Teodoro de Carvalho   +6 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Response and resistance to BET bromodomain inhibitors in triple negative breast cancer

Nature, 2016
Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. BET bromodomain inhibitors, which have shown efficacy in several models of cancer, have not been evaluated in TNBC.
Shaokun Shu, Charles Y. Lin, H. He, R. Witwicki, D. Tabassum, Justin M. Roberts, M. Janiszewska, S. Huh, Yi Liang, J. Ryan, Ernest Doherty, H. Mohammed, Hao Guo, D. Stover, Muhammad B. Ekram, Guillermo Peluffo, Jonathan D. Brown, C. D'Santos, I. Krop, D. Dillon, M. McKeown, C. Ott, J. Qi, M. Ni, P. Rao, Melissa Duarte, Shwu-Yuan Wu, Cheng-Ming Chiang, L. Anders, R. Young, E. Winer, A. Letai, W. Barry, J. Carroll, Henry W. Long, Myles A. Brown, X. Liu, Clifford A. Meyer, J. Bradner, K. Polyak   +39 more
semanticscholar   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

Molecules and Cells, 2017
SUMMARY Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory factors influence transcription elongation on a global scale. Prior research using small-
G. Winter, A. Mayer, Dennis L. Buckley, Michael A. Erb, J. Roderick, S. Vittori, Jaime M. Reyes, J. di Iulio, Amanda L. Souza, C. Ott, Justin M. Roberts, Rhamy Zeid, Thomas G. Scott, Joshiawa Paulk, Kate C. Lachance, C. Olson, S. Dastjerdi, Sophie Bauer, Charles Y. Lin, N. Gray, M. Kelliher, L. Churchman, J. Bradner   +22 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

ANALYSIS OF TIME-ZONE RELATIONSHIP TO EPHEMERIS DATA RETRIEVAL IN CALCULATING THE BEGINNING OF JEMBRANA-BANYUWANGI PRAYER TIMES

Al-Hilal
The calculation of prayer times in Bali and Banyuwangi Regency often needs to be clarified. Hasib suggests Bali's prayer time calculations could refer to those in Banyuwangi due to their close astronomical coordinates.
Agus Setya, Youla Afifah Azkarrula
doaj   +1 more source