Results 131 to 140 of about 10,836 (202)

Finn Waagstein and the paradigm shift in the treatment of heart failure with β-adrenergic receptor antagonists ('β-blockers'). [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Lorenz K, Ravens U.
europepmc   +1 more source

A Structural Context for the Mechanisms of Uncoupling Protein 1 in Brown Fat Thermogenesis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Uncoupling Protein 1 (UCP1) is a defining feature of brown fat and facilitates the specialized ability of the tissue to generate heat in the process of non‐shivering thermogenesis. The protein is activated by fatty acids, which overcome its inhibition by purine nucleotides, to catalyze proton leak across the mitochondrial inner membrane ...
Riccardo Cavalieri, Margeoux A. S. Dela Rosa, Camila A. Cotrim, Danielle Copeman, Mehmethan Aris, Callum Eke, Hannah Staggs‐Sandy, Paul G. Crichton   +7 more
wiley   +1 more source

TRIC-A Loss Sensitizes the Heart to β-Adrenergic Stress and Drives Cardiomyocyte Death and Fibrosis. [PDF]

Biomolecules
Park KH, Yamazaki D, Zhou X, Komazaki S, Zhao C, Nishi M, Zhou J, Takeshima H, Ma J.   +8 more
europepmc   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

Berberine ameliorates acute hyperglycemia and hypoinsulinemia induced by ketamine/xylazine in rats: role of alpha₂ adrenergic receptors, oxidative stress and inflammatory suppressing mechanisms. [PDF]

BMC Vet Res
Kadhim RA, Erfanparast A, Tamaddonfard E, Amirkashani D, Imani M.   +4 more
europepmc   +1 more source

G-protein coupled receptors synergy in bone health: new avenues for osteoporosis detection and <i>in vitro</i> modeling. [PDF]

Front Endocrinol (Lausanne)
Sopova JV, Krasnova OA, Kriukova JD, Mukhamedshina YO, Zakirova EY, Rizvanov AA, Lesnyak OM, Neganova IE.   +7 more
europepmc   +1 more source

GGAs: Regulation of Multiple Sorting Pathways and Potential Association With Human Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Golgi‐localized gamma‐ear‐containing Arf‐binding proteins (GGAs) are a family of monomeric clathrin adaptors that function in intracellular vesicle trafficking. The three GGA family members—GGA1, GGA2 and GGA3—were first identified as sorting adaptors almost simultaneously by independent research groups in 2000. It is now well established that
Qinqin Wang, Juan Mei, Shuyue Li, Guoan Zhang, Jian Qiu, Xuezhi Li   +5 more
wiley   +1 more source

STAT1/3/5 Functions Driving Lipid and Energy Metabolism in Cancer and Immunity. [PDF]

Int J Mol Sci
Rinnerthaler M, Sykora M, Christoforakos A, Aberger F, Ferbeyre G, Moriggl R.   +5 more
europepmc   +1 more source

Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi, Ali Saeedi‐Boroujeni, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +4 more
wiley   +1 more source

Cirrhotic Cardiomyopathy: Bridging Hepatic and Cardiac Pathophysiology in the Modern Era. [PDF]

J Clin Med
Lupu D, Scârneciu CC, Țînț D, Tudoran C.   +3 more
europepmc   +1 more source