Results 121 to 130 of about 2,017,300 (180)

International Utah cardiac recovery symposium (U-CARS) 2025:translational and basic science proceedings. [PDF]

Heart Fail Rev
Visker JR, Tseliou E, Drosatos K, Wever-Pinzon O, Holland W, Drakos SG.   +5 more
europepmc   +1 more source

Sirtuin signalling governs calcium homeostasis and mitochondrial function in metabolic syndrome cardiomyocytes

Experimental Physiology, Volume 111, Issue 10, Page 4646-4658, 1 October 2026.
Abstract Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca2+ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these alterations remain incompletely defined.
Firat Akat, Leila Aryan, Suatnur Şık, Erkan Tuncay   +3 more
wiley   +1 more source

Exploratory Analysis of the Inhibitory Effects of Propranolol on NLRP3 and Pyrin Inflammasomes. [PDF]

ACR Open Rheumatol
de Jong RJ, Neullens CT, Swoboda A, Saers M, Berger P, Hebbar Subramanyam S, Wiener A, Ohl K, Weiskirchen R, Noels H, Kallinich T, Guthrie J, Kessel C, Tenbrock K.   +13 more
europepmc   +1 more source

General Assessment of Indole Derivatives and Wnt Pathway as Potential Key Factors Against Various Diseases, with Particular Emphasis on Thyroid Tumors. [PDF]

Int J Mol Sci
Skoczyńska AK, Lewiński A, Karbownik-Lewińska M.   +2 more
europepmc   +1 more source

Molecular Mechanisms Underlying Recurrence in Triple-Positive Breast Cancer (ER+/PR+/HER2+) and Potential Repurposing of Multi-Target Inhibitors. [PDF]

Int J Mol Sci
Bandala C, López-Méndez JA, Díaz-Rivera MRJ, Carro-Rodríguez J, Bello M.   +4 more
europepmc   +1 more source

Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β‐Adrenoceptor Stimulation

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Annexin A4 (A4) inhibits adenylyl cyclase 5 and may protect the heart during chronic β‐adrenergic stress. After 7 days of isoprenaline, A4‐deficient mice showed greater cardiomyocyte hypertrophy, prolonged action potentials, reduced Ito, preserved ICaL with altered activation, increased NCX1, and enhanced acute cAMP responsiveness compared with wild ...
Florentina Pluteanu, Alexander Heinick, Manuel Domnik‐Lehnert, Frank U. Müller, Christina Hermes   +4 more
wiley   +1 more source

The neuronal network of small cell lung cancer: a narrative review of the role of the nervous system in the pathogenesis and progression. [PDF]

Transl Lung Cancer Res
Gap M, Gajewski F, Pająk W, Pec J, Kleinrok J, Kurec G, Krawczyk P.   +6 more
europepmc   +1 more source

Oxadiazolone‐Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II‐Induced Vascular Contraction

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
A novel series of candidate AT1 receptor antagonists based on oxadiazolone‐triazole scaffolds was designed and synthesized. Most compounds reduced angiotensin II‐induced vascular contraction in an initial biological screening, with compound 7f emerging as the most active derivative.
Larissa F. L. Ferreira, Daiana G. de A. Vasconcelos, Ruth C. A. Santos, Jivaldo G. Ferreira, Alice V. Araújo, Janaína V. dos Anjos   +5 more
wiley   +1 more source

The slow delayed rectifier K⁺ current is differently regulated under baseline conditions and following β-adrenergic stimulation in canine ventricular cardiomyocytes. [PDF]

Sci Rep
Horváth B, Kovács Z, Dienes C, Óvári J, Szentandrássy N, Magyar J, Bányász T, Nánási PP.   +7 more
europepmc   +1 more source

Muscle Loss Driven by Extracellular Signal-Regulated Kinase Suppression via β-Adrenergic Activation in High-Normal Catecholamine Status. [PDF]

Endocrinol Metab (Seoul)
Lee J, Kwak JY, Lee HY, Moon JS, Jang HJ, Nga HT, Nguyen TL, Abdillah AM, Kim J, Kim S, Yang YR, Lee JE, Yi HS.   +12 more
europepmc   +1 more source