Results 171 to 180 of about 28,675 (270)

Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice. [PDF]

Nat Commun
Fu H, Lee S, Zemke NR, Fan W, Wang Y, Garza J, Tin D, Villao B, Zhang B, Ma X, Zhang J, Dong T, Ren Y, Downes M, Evans RM, Ren B, Saltiel AR.   +16 more
europepmc   +1 more source

G Protein‐Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
ABSTRACT Stimulation of nociceptin/orphanin FQ peptide (NOP) opioid receptors by the endogenous ligand nociceptin (Noc) leads to voltage‐gated Ca2+ channel inhibition or G protein inwardly rectifying K+ channel activation. One mechanism of G protein‐coupled receptor (GPCR) desensitization occurs when G protein‐coupled receptor kinases (GRK ...
Mohamed Farrag, Marwa Soliman, Saifeldin Mahmoud, Lauren Miller, Paul B. Herold, Kristen Brandt, Victor Ruiz‐Velasco   +6 more
wiley   +1 more source

Desensitization of the turkey erythrocyte beta-adrenergic receptor in a cell-free system. Evidence that multiple protein kinases can phosphorylate and desensitize the receptor.

, 1985
P Nambi, J R Peters, David R. Sibley, R J Lefkowitz   +3 more
openalex   +1 more source

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia‐Reperfusion Injury

MedComm, Volume 7, Issue 1, January 2026.
We employed spatially resolved transcriptomics to visualize and molecularly characterize the spatial distribution of gene expression profiles in the rats’ left ventricles following MIR injury. Further experiments indicated that cardiogenic Piezo1‐mediated calcium overload exacerbates MIR through the activation of matrix metalloproteinase 2‐ryanodine ...
Zhen Li, Fan Jiang, Yan Chen, Zhixiao Li, Yanqiong Wu, Zhigang He, Duozhi Wu, Hongbing Xiang   +7 more
wiley   +1 more source

Chronic stress-related neuroendocrine mediators and ovarian cancer. [PDF]

Discov Oncol
Du H, Yu G, Hu R, Du J, Liu C.
europepmc   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Isoprenaline shows unique kinase dependencies in stimulating β₁AR-β-arrestin2 interaction compared to endogenous catecholamines. [PDF]

Mol Pharmacol
Matthees ESF, Kletzin LE, Löbbert A, Hoffmann JS, Große C, Gossert AD, Hoffmann C.   +6 more
europepmc   +1 more source

Activity‐restoring mutations in the histamine H3 receptor increase constitutive activity and reduce structural stability

Protein Science, Volume 35, Issue 1, January 2026.
Abstract The histamine H3 receptor (H3R) is a class A G protein‐coupled receptor (GPCR) that regulates neurotransmitter release in the central nervous system. Although structures of H3R in both inactive and active states have been elucidated, the functional roles of specific residues remain unclear.
Ami Nakajima, Hiroto Kaneko, Kosuke Oyama, Misumi Kuchiji, Ayane Itakura, Chiaki Arai, Mitsunori Shiroishi   +6 more
wiley   +1 more source

Cardioprotective Signaling: Outline and Future Directions. [PDF]

Biomedicines
Jovanović A.
europepmc   +1 more source

Beta‐3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline‐Induced Pulmonary Hypertension Model

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Considering the beta‐3 adrenoceptor agonist, mirabegron, may display vasodilator and cardioprotective properties, we investigated the therapeutic potential of mirabegron in monocrotaline‐induced pulmonary hypertension in rats. High‐dose mirabegron improved right ventricular function, and endothelium‐dependent relaxation in isolated rat ...
Pedro Mendes‐Ferreira, Birger Tielemans, Allard Wagenaar, Caroline Bouzin, Rui Adão, Peter Pokreisz, Delphine De Mulder, Adelino Leite‐Moreira, Carmen Brás‐Silva, Jean‐Luc Balligand, Chantal Dessy, Marion Delcroix, Rozenn Quarck, Catharina Belge   +13 more
wiley   +1 more source