Results 191 to 200 of about 28,193 (228)

Drug Repositioning in Doxorubicin-Induced Cardiotoxicity Protection. [PDF]

open access: yesInt J Mol Sci
Kosić M   +3 more
europepmc   +1 more source

GPCR-Mediated Cell Intelligence: A Potential Mechanism for Survival and Long-Term Health. [PDF]

open access: yesCurr Issues Mol Biol
Craig CJ   +4 more
europepmc   +1 more source
Some of the next articles are maybe not open access.

Phosphorylation of chick heart muscarinic cholinergic receptors by the .beta.-adrenergic receptor kinase

Biochemistry, 1989
Previous studies have demonstrated that muscarinic cholinergic receptors (mAChR) become markedly phosphorylated when intact cardiac cells are stimulated with a muscarinic agonist. This process appears to be related to the process of receptor desensitization. However, the mechanism of agonist-induced phosphorylation of mAChR is not known.
M M, Kwatra   +4 more
openaire   +2 more sources

The β-adrenergic receptor kinase in heart failure

Journal of Molecular and Cellular Cardiology, 2003
Heart failure (HF) remains a significant and increasing cause of worldwide morbidity and mortality. HF is less a disease than a common clinical endpoint resulting from diverse, but often co-existing etiologies-including hypertension, coronary artery disease, and viral cardiomyopathy.
Jason A, Petrofski, Walter J, Koch
openaire   +2 more sources

Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine

American Journal of Physiology-Heart and Circulatory Physiology, 1997
To determine the direct functional significance of the beta-adrenergic receptor (AR) kinase 1 (beta ARK1) on myocardial performance in the absence of tonic sympathoadrenal neural activation and mechanical loading, we measured the contractile responses to acute beta 1-AR stimulation in left ventricular myocytes isolated from nontransgenic control (NTG)
D H, Korzick   +5 more
openaire   +2 more sources

Molecular Cloning, Functional Expression and mRNA Analysis of Human Beta-Adrenergic Receptor Kinase 2

Biochemical and Biophysical Research Communications, 1993
In the present study the cDNA of human beta ARK2 was cloned using both PCR and cDNA library screening, subcloned into an expression vector and transiently expressed in COS7 cells. The expressed kinase activity was approximately 40% as efficient as human beta ARK1 in phosphorylating bovine rod outer segments in vitro. Northern blot analysis of human and
Parruti G   +3 more
openaire   +2 more sources

Serum creatine kinase release and alpha- and beta-adrenergic receptors.

Archives internationales de pharmacodynamie et de therapie, 1986
Changes in the serum creatine kinase (CK) activity and the mechanism of its release after administration of two kinds of beta-blockers to rats were studied in order to determine the mechanism of the increase in serum CK accompanying administration of beta-blockers.
Y, Jingu, Y, Aoki, H, Itoh, T, Saruta
openaire   +1 more source

Involvement of protein kinase in the regulation of beta-adrenergic receptors by antidepressants.

International journal of clinical pharmacology research, 1989
The role of serotonin (5-HT) and protein kinases in the regulation of the beta-receptor induced by typical and atypical antidepressants was investigated. Treatment with either mianserin or maprotiline for seven days produced a significant decrease in the beta-receptor density measured 6h after the last dose.
M, Asakura   +9 more
openaire   +1 more source

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