Results 71 to 80 of about 749,005 (154)

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, EarlyView.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

Phi Beta Kappa Minutes, December 5, 1776-January 6,1781 [PDF]

Ledger of the Phi Beta Kappa minutes of meetings from December 5, 1776-January 6, 1781. These are the earliest meetings of Phi Beta Kappa.
Phi Beta Kappa
core  

Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.

, 2008
The internalization properties of the alpha1a- and alpha1b-adrenergic receptors (ARs) subtypes transiently expressed in human embryonic kidney (HEK) 293 cells were compared using biotinylation experiments and confocal microscopy.
Abuin, L., Cotecchia, S., Stanasila, L., Dey, J.   +3 more
core   +1 more source

Phi Beta Kappa: The Key Reporter Winter 2012-2013

, 2012
Announcement of the Beta of Nebraska chapter installation at Creighton University, p.
Phi Beta Kappa Society
core  

Catalytic activation of beta-arrestins allows novel trafficking and signaling functions [PDF]

, 2017
This thesis examines the trafficking and signaling functions of beta-arrestins, a highly conserved class of proteins that are critical regulators of G protein coupled receptor function (GPCRs), a large family of seven-transmembrane signaling receptors ...
Eichel, Kelsie
core  

Phi Beta Kappa, Alpha Chapter Records [PDF]

, 1875
Phi Beta Kappa was founded by five students at the College of William and Mary in 1776. This minute book documents the organization in the period 1875-1905.
Phi Beta Kappa, College of William and Mary. Students   +1 more
core  

I rivali di Aristofane

, 2002
Partendo dalla recente pubblicazione di un volume curato da D. Harvey e J. Wilkins (The rivals of Aristophanes. Studies in Athenian Old Comedy, London 2000), Simone Beta discute sull'importanza dello studio dei frammenti comici per una conoscenza ...
BETA, SIMONE, Simone Beta
core   +1 more source

La danza, a cura di Simone Beta. Traduzione di Marina Nordera, con testo a fronte

, 1992
Il volume consiste nella traduzione italiana (per opera di Marina Nordera) del trattato La danza (De saltatione) di Luciano. L'introduzione (pp. 9-47), le note al testo (pp. 111-138) e la bibliografia (pp. 139-142) sono di Simone Beta.
BETA, SIMONE, Nordera M.
core   +1 more source