Results 91 to 100 of about 15,347,884 (286)

Risk management externalities in agrifood supply chains

American Journal of Agricultural Economics, EarlyView.
Abstract Firms may under‐ or over‐invest in risk management from the social planner's perspective, resulting in a negative externality on other economic agents in the supply chain. The externality of risk management is particularly relevant for agrifood supply chains, which frequently experience disruptions and play a primary role in preventing major ...
Jeffrey Hadachek, Meilin Ma
wiley   +1 more source

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation

American Journal of Hematology, EarlyView.
ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part ...
Marilou Tetard, Tianjian Lin, Nana A. Peterson, Rebekah C. Gullberg, Yann Le Guen, Jasmine Moshiri, John G. Doench, Elizabeth S. Egan   +7 more
wiley   +1 more source

Assessment of outcome measures for cost–utility analysis in depression: mapping depression scales onto the EQ-5D-5L

BJPsych Open, 2018
BackgroundMany clinical studies including mental health interventions do not use a health state utility instrument, which is essential for producing quality-adjusted life years. In the absence of such utility instrument, mapping algorithms can be applied
Thor Gamst-Klaussen, Admassu N. Lamu, Gang Chen, Jan Abel Olsen   +3 more
doaj   +1 more source

Bayesian Inference for Three Bivariate Beta Binomial Models [PDF]

The Open Statistics & Probability Journal, 2017
Background:This paper considers three two-dimensional beta binomial models previously introduced in the literature. These were proposed as candidate models for modelling forms of correlated and overdispersed bivariate count data. However, the first model has a complicated form of bivariate probability mass function involving a generalized ...
openaire   +1 more source

Beta Regression in R [PDF]

The class of beta regression models is commonly used by practitioners to model variables that assume values in the standard unit interval (0, 1). It is based on the assumption that the dependent variable is beta-distributed and that its mean is related ...
Achim Zeileis, Francisco Cribari-Neto
core  

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Pathological nodal staging score for rectal cancer patients treated with radical surgery with or without neoadjuvant therapy: a postoperative decision tool

Cancer Management and Research, 2019
Weixing Dai,1,2,* Yaqi Li,1,2,* Zhenyu Wu,3,* Yang Feng,1,2 Sanjun Cai,1,2 Ye Xu,1,2 Qingguo Li,1,2 Guoxiang Cai1,2 1Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; 2Department of Oncology, Shanghai ...
Dai W, Li Y, Wu Z, Feng Y, Cai S, Xu Y, Li Q, Cai G   +7 more
doaj  

The impact of viral and host factors on the influenza A virus transmission bottleneck.

PLoS Pathogens
Transmission bottlenecks are defined by the number of unique virions or genotypes that establish an infection, and they restrict viral diversity that passes from one infected host to another.
Kathryn C Krupinsky, Emily E Bendall, Yuwei Zhu, Melissa S Stockwell, Huong Q Nguyen, Jennifer K Meece, Yvonne Maldonado, Katherine D Ellingson, Karen Lutrick, Edwin J Asturias, Suchitra Rao, Natalie M Bowman, Melissa Rolfes, Jessica E Biddle, Alexandra Mellis, Jonathan E Schmitz, James D Chappell, Natasha B Halasa, William J Fitzsimmons, Emily T Martin, Carlos G Grijalva, H Keipp Talbot, Adam S Lauring   +22 more
doaj   +1 more source

Circulating Exosomes Drive Persistent Neuronal Dysfunction in Post‐Herpetic Neuralgia Patients

Annals of Neurology, EarlyView.
Proposed model of exosome‐mediated neuronal dysfunction in post‐herpetic neuralgia (PHN). (1) Circulating, non‐pathogenic exosomes maintain homeostatic processes in healthy skin, where sensory nerve fibers innervate the epidermis and dermis. (2) During acute zoster, reactivating varicella zoster virus (VZV) travels down neurites to the skin causing ...
Christy S. Niemeyer, Seth Frietze, Serena W.R. Lewis, Emily C. Artman, Christina Coughlan, Safa I. Vaseemuddin, Arianna Gentile Polese, Maria A. Nagel, Stephen K. Tyring, Fyona Okundia, Anthony J. Saviola, Gary C. Curhan, Sharon G. Curhan, Diego Restrepo, Andrew N. Bubak   +14 more
wiley   +1 more source

An Application of Beta Binomial GAMLSS for the Estimate of Surrender Rates

This paper deals with the estimate of surrender rate with explanatory variables by a Generalized Linear Model for Location, Scale, and Shape (GAMLSS) where the response variable is assumed Beta Binomial. In actuarial practice and literature, the Binomial
De Angelis, Paolo, Biancalana, Davide, Baione, Fabio   +2 more
core   +1 more source