Results 61 to 70 of about 15,347,884 (286)

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

A Bimodal Extension of the Beta-Binomial Distribution with Applications

Axioms
In this paper, we propose an alternative distribution to model count data exhibiting uni/bimodality. It arises as a weighted version of the beta-binomial distribution, which is defined by a parametric weight function that admits up to two modes for the ...
Jimmy Reyes, Josu Najera-Zuloaga, Dae-Jin Lee, Jaime Arrué, Yuri A. Iriarte   +4 more
doaj   +1 more source

Estimating density of secretive terrestrial birds (Siamese Fireback) in pristine and degraded forest using camera traps and distance sampling

Global Ecology and Conservation, 2015
Tropical Asian Galliformes are secretive and difficult to survey. Many of these species are considered “at risk” due to habitat degradation although reliable density estimates are lacking. Using camera trapping and distance sampling data collected on the
Saranphat Suwanrat, Dusit Ngoprasert, Christopher Sutherland, Pongthep Suwanwaree, Tommaso Savini   +4 more
doaj   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

Comparison of the accuracy of beta-binomial, multinomial, dirichlet-multinomial, and ordinal regression in modelling quality of life data

Journal of Biostatistics and Epidemiology, 2018
Background & Aim: Questionnaires are used mostly as a tool in medical research. Due to the different varieties of questionnaires, we may face different score distributions. In many cases multiple linear regression assumptions are violated.
Ali Ghanbari, Mir Saeed Yekaninejad, Amir Pakpour, Sobhan Sanjari, Keramat Nourijelyani   +4 more
doaj  

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

A spatial beta-binomial model for clustered count data on dental caries [PDF]

Statistical Methods in Medical Research, 2010
One of the most important indicators of dental caries prevalence is the total count of decayed, missing or filled surfaces in a tooth. These count data are often clustered in nature (several count responses clustered within a subject), over-dispersed as well as spatially referenced (a diseased tooth might be positively influencing the decay process of ...
Dipankar, Bandyopadhyay, Brian J, Reich, Elizabeth H, Slate   +2 more
openaire   +2 more sources

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Empirical-distribution-function tests for the beta-binomial model

, 2010
碩士本文主要是探討應用經驗分布函數對貝他-二項式模式做適合度檢定. 我們提出兩種以經驗分布函數為基礎之統計量的檢定方法, 然後透過蒙地卡羅模擬研究去檢定統計量在對立假設下之不同分布的經驗檢定力. 與 Garren et al. (2001) 的方法相比較, 我們的方法在大多數的情況下是具有較大檢定力的.
周正杰; Chou, Cheng-chieh
core   +1 more source

Gaussian Copula Regression in R

Journal of Statistical Software, 2017
This article describes the R package gcmr for fitting Gaussian copula marginal regression models. The Gaussian copula provides a mathematically convenient framework to handle various forms of dependence in regression models arising, for example, in time ...
Guido Masarotto, Cristiano Varin
doaj   +1 more source