Results 111 to 120 of about 126,356 (297)
Beta-blockers: friend or foe in asthma?
International Journal of General Medicine, 2013 Bente Arboe, Charlotte Suppli UlrikDepartment of Pulmonary Medicine, Hvidovre Hospital and University of Copenhagen, Hvidovre, DenmarkBackground and aim: Recently, β-blockers have been suggested as a potential maintenance treatment option for asthma.
Arboe B, Ulrik CS
doaj
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension
Blood Pressure, 2017 Objectives: Suboptimal medication adherence is common among patients with hypertension. Measurements of plasma or urinary levels of antihypertensive drugs are useful, but not widely available.
Eva Kociánová +8 more
doaj +1 more source
St. Mary's Health Center: Focus on Core Measures Improves Quality [PDF]
, 2009 Describes strategies that greatly improved process-of-care measures, including communication through physician-led committees and peers, standardization through order sets, concurrent and retrospective chart reviews, and transparency and data ...
Sharon Silow-Carroll
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Beta-adrenoblockers: treatment principles in international clinical guidelines
Кардиоваскулярная терапия и профилактика, 2005 The article contains data on beta-blocker efficacy in cardiology – the results of large, randomized clinical trials, and evidence-based clinical guidelines on beta-blocker therapy.
S. Yu. Martsevich
doaj
Flowers Hospital: Nearing Perfection on Core Measures [PDF]
, 2008 Describes elements of a strategy for achieving high process-of-care performance by continuously monitoring patients in four clinical areas and ensuring they receive the right care -- including concurrent reviews and quality improvement ...
Jennifer N. Edwards
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Luther Midelfort Mayo Health System: Laying Tracks for Success [PDF]
, 2008 Describes strategies for establishing a culture of experimentation, including creating interdisciplinary teams to decide the content of care and providing timely measurement and ...
Jennifer N. Edwards
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